et-a — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5458	Darusentan	Lu-135252	Endothelin Receptor
	Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries		Endothelin Receptor
T35347	Et-29	NRD167	Sirtuin
	Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.		Sirtuin
T31640	Enrasentan	SB-217242,SB 217242,SB217242	Endothelin Receptor
	Enrasentan (sb-217242) is a mixed antagonist of ET(A) and ET(B) receptors that reduces blood pressure, prevents cardiac hypertrophy, and protects myocardial function.		Endothelin Receptor
TP1174	Endothelin-2 (49-69), human	Human endothelin-2,Endothelin-2, human,Endothelin-2 (human, canine)	Others
	Endothelin-2 (49-69), human (Human endothelin-2) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.		Others
T10595	BQ-788	BQ788	Endothelin Receptor
	BQ-788 is a selective and potent ETB receptor antagonist with potential hypertensive activity.BQ-788 inhibits ET-1 binding to ETB receptors and inhibits exogenous ET-1-induced elevation of coronary artery perfusion press...		Endothelin Receptor
T6265	Bosentan (hydrate)	Bosentan Hydrate,Benzenesulfonamide,Actelion,Ro 47-0203	Endothelin Receptor
	Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.		Endothelin Receptor
T22286	Cyanosafracin B	Cyanoquinonamine,CBR28-1	Others
	Cyanosafracin B (Cyanoquinonamine) is a compound which can be used in the synthesis of ecteinascidin ET-743 (an antitumor chemotherapy drug).		Others
TN7122	Micromarin F	E-Methylarnottinin,5'-hydroxylosthole	Others
	Micromarin F (E-Methylarnottinin) is a coumarin derivative extracted from the stems of Micromelum minutum Wight et Arn.		Others
T14219	Aminaftone	Aminaphthone	Endothelin Receptor
	Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and can be used to study hypertension and systemic sclerosis.		Endothelin Receptor
TN3029	4-(Ethoxymethyl)phenol	p-Hydroxybenzyl Et ether	Antioxidant
	4-(Ethoxymethyl)phenol (p-Hydroxybenzyl Et ether) is a small molecule compound extracted from Amburana cearensis with cytotoxic and antioxidant activity.		Antioxidant
T34541	SB-209670	SB 209670	Endothelin Receptor
	SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.		Endothelin Receptor
T4570	Pipobroman	Vercyte,A-8103,Amedel	Others , DNA Alkylator/Crosslinker
	Pipobroman (Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET). Pipobroman allows, wit...		Others , DNA Alkylator/Crosslinker
T6258	Zibotentan	ZD4054	Apoptosis , Endothelin Receptor
	Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.		Apoptosis , Endothelin Receptor
T22540L	Ac-Endothelin-1 (16-21), human acetate		Others
	Ac-Endothelin-1 (16-21), human acetate, the principal peptide of the endothelin family, has been shown to have a variety of biological activities in both vascular and nonvascular tissues. The C-terminal fragment, which i...		Others
T9522	Rimtuzalcap	CAD-1883	Potassium Channel
	Rimtuzalcap (CAD-1883) (CAD-1883), a pioneering selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels), is employed in the study of movement disorders such as spin...		Potassium Channel
T37807	JTV 519 fumarate
	Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo. Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]r...
T3194	Ro 46-2005		Endothelin Receptor
	Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor, IC50: 220 nM).		Endothelin Receptor
T37345	5,7-Dihydroxycoumarin		Antibacterial
	5,7-Dihydroxycoumarin is a coumarin isolated from the inflorescences of Macaranga triloba. 5,7-Dihydroxycoumarin has antibacterial activities[1][2]. [1]. Ishak Zakaria, et al. Flavonoids with antiplasmodial and cytotoxic...		Antibacterial
T3019	Physcion	Physcione,Parietin,Rheochrysidin	Dehydrogenase , Antibacterial
	Physcion (Physcione) (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM...		Dehydrogenase , Antibacterial
T36914	2-Hydroxyanthraquinone		Others
	2-Hydroxyanthraquinone is an anthraquinone that has been found inSpermacoce latifoliaand has antibacterial and estrogenic activities.1,2It is active againstB. subtilisandB. cereus(MICs = 1.9 and 62.5 μg/ml, respectively)...		Others