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Endothelin-2 (49-69), human

Catalog No. TP1174 CAS 123562-20-9

Synonyms: Human endothelin-2, Endothelin-2, human, Endothelin-2 (human, canine)

Endothelin-2 (49-69), human (Human endothelin-2) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

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Endothelin-2 (49-69), human Chemical Structure

Endothelin-2 (49-69), human, CAS 123562-20-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 346.00
5 mg	In stock	$ 713.00
10 mg	In stock	$ 987.00
25 mg	In stock	$ 1,480.00
50 mg	In stock	$ 1,980.00

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Purity: 98.26%

Biological Description

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Storage & Solubility Information

Description	Endothelin-2 (49-69), human (Human endothelin-2) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.
In vitro	At nanomolar concentrations, Endothelin-2 significantly induces strong and persistent vasoconstriction, similar to the effects observed with other endothelins (EC50=0.52 nM)[1]. It functions as a potent chemoattractant specifically for macrophages and THP-1 monocytic cells, but does not attract freshly isolated monocytes. The chemotactic activity towards Endothelin-2 demonstrates a characteristic bell-shaped curve. Research utilizing endothelin receptor antagonists has revealed that the ET-RB receptor mediates the directed cell migration towards Endothelin-2. Moreover, the presence of Endothelin-2 in tumor environments suggests it plays a role in modifying macrophage behavior, leading to the accumulation of activated macrophages in hypoxic regions.
In vivo	Rats[1] For the assay of pressor activity, male Wistar rats weighing 300-350 g are anesthetized with urethane (1 g/kg i.p.) and pretreated with atropine (0.25 mg/kg i.v.), propranolol (1 mg/kg i.v.), and bunazocine (1 mg/kg i.v.). Additional maintenance doses (one-half of the initial doses) of the autonomic blockades are administered every 3-4 hr. Each animal is given only one bolus of Endothelin-2. 1 nM of Endothelin-2 in 50 渭L of buffer is bolus injected from a cannula inserted in the right femoral vein. The blood pressure is recorded from a cannula, which is placed in the right carotid artery and connected to a pressure transducer[1].

Synonyms	Human endothelin-2, Endothelin-2, human, Endothelin-2 (human, canine)
Molecular Weight	2546.92
Formula	C115H160N26O32S4
CAS No.	123562-20-9

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Soluble

References and Literature

1. Grimshaw MJ, et al. Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. Eur J Immunol. 2002 Sep;32(9):2393-400.

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Keywords

Endothelin-2 (49-69), human 123562-20-9 Others peptide Endothelin-2 , human Human endothelin-2 21-amino inhibit Human endothelin 2 vasoactive acid ET-RB Endothelin 2 (49 69), human Endothelin-2, human Endothelin2 (4969), human Human endothelin2 ET-RA Endothelin-2 (human, canine) Endothelin-2 Inhibitor transmembrane inhibitor

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