Search Result

Search Results for " dgat "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T11016	DGAT-1 inhibitor 2		Transferase
	DGAT-1 inhibitor 2 is an effective DGAT-1 inhibitor; anti-obesity drug. Objective: DGAT-1 acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step of triglyceride s...		Transferase
T4681	T863	DGAT-3,DGAT-1 inhibitor	Acyltransferase , Transferase
	T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis...		Acyltransferase , Transferase
T6365	A 922500	A922500,DGAT-1 Inhibitor 4a	Acyltransferase , Transferase
	A 922500 (DGAT-1 Inhibitor 4a) is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets.		Acyltransferase , Transferase
T27691	JNJ-DGAT2-A	JNJDGAT2A	Transferase
	JNJ-DGAT2-A, a specific inhibitor of DGAT2(IC50 = 0.14 μM), can be used in studies about the synthesis of triglycerides.		Transferase
T15109	DGAT1-IN-1		Transferase
	DGAT1-IN-1 is a potent inhibitor of diacylglycerol O- acyltransferase type 1(DGAT1, IC50 of < 10 nM).		Transferase
T27690	JNJ-DGAT1-A
	JNJ-DGAT1-A is a DGAT1-selective inhibitor.
T27692	JNJ-DGAT2-B	JNJDGAT2B,JNJ DGAT2 B
	JNJ-DGAT2-B is a selective inhibitor of Diacylglycerol acyltransferase 2.
T62220	DGAT1-IN-3
	DGAT1-IN-3 is a selective, potent, orally active DGAT-1 inhibitor that inhibits human DGAT-1 (IC50: 38 nM) and rat DGAT-1 (IC50: 120 nM).DGAT1-IN-3 can be used in studies of obesity, dyslipidemia and metabolic syndrome.
T14375	AZD3988		Transferase
	AZD3988 is an orally active and highly potent inhibitor of diacylglycerol acyltransferase-1 (DGAT-1) for the study of diabetes and obesity.		Transferase
T12425	PF-06424439 methanesulfonate		Acyltransferase , Transferase
	PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inh...		Acyltransferase , Transferase
T6937	PF-04620110	PF04620110,PF 04620110	Acyltransferase , Transferase
	PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.		Acyltransferase , Transferase
T25978	Pradigastat sodium	LCQ 908ABA,LCQ-908ABA,LCQ 908,LCQ-908,LCQ908ABA
	Pradigastat sodium is a novel inhibitor of DGAT-1.
T14085	ABT-046		Others
	ABT-046 is an acyl CoA:diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC50= 8 nM)[1]		Others
T74420	Obeversen
	Obeversen is a DGAT-2 synthesis reducer [1] .
T71886	ALN29882
	ALN29882 is a glycerolipid, that is located at the plasma membrane. It is made up of two fatty acid chains that are covalently attached to a single glycerol molecule with the help of an ester linkage. 18:1 DG has been u...
T11491	GSK2973980A		Transferase
	GSK2973980A is a selective Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitor (IC50: 3 nM).		Transferase
T12426	PF-06424439		Acyltransferase , Transferase
	PF-06424439 is an oral and selective inhibitor of imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) (IC50 of 14 nM).		Acyltransferase , Transferase

Compounds

Synonym: DGAT-3,DGAT-1 inhibitor

Target: Acyltransferase, Transferase

A 922500

T6365

Synonym: A922500,DGAT-1 Inhibitor 4a

Target: Acyltransferase, Transferase

Synonym: JNJDGAT2B,JNJ DGAT2 B

PF-06424439 methanesulfonate

T12425

Synonym:

Target: Acyltransferase, Transferase

PF-04620110

T6937

Synonym: PF04620110,PF 04620110

Target: Acyltransferase, Transferase

Pradigastat sodium

T25978

Synonym: LCQ 908ABA,LCQ-908ABA,LCQ 908,LCQ-908,LCQ908ABA

Target: Acyltransferase, Transferase

Cat No.	Product Name	Synonyms	Targets
T3342	Xanthohumol		Apoptosis , Others , Influenza Virus , COX , Acyltransferase , HSV
	Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows ...
TN3257	7beta-Methoxyrosmanol		Transferase
	7beta-Methoxyrosmanol inhibited acyl CoA:diacylglycerol acyltransferase (DGAT)1 activity, with the IC50 values ranging from 39.5 ± 0.6 to 144.2 ± 3.1 μM.		Transferase
TN1843	Kushenol K		PDE , HSV
	Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K shows weak antiviral activity against Herpes simplex virus t...		PDE , HSV
TN3255	7beta-(3-Ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone		Others
	7beta-(3-Ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone shows diacylglycerol acyltransferase (DGAT)1 inhibition with IC(50) values of 47.0 microM (for rat liver microsomes) and 160.7 m...		Others
TN3428	Aphadilactone C		Others
	Aphadilactone C shows significant antimalarial activity with the IC50 value of 170 ± 10 nM. It shows potent and selective inhibition against the diacylglycerol O-acyltransferase-1 (DGAT-1) enzyme (IC50 = 0.46 ± 0.09 uM, ...		Others
T69446	Cochlioquinone A
	Cochlioquinone A is an inhibitor of diacylglycerol kinase (DGK) and diacylglycerol acyltransferase (DGAT). It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma and has also been shown to ...
T37690	Phenylpyropene A
	Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM)....
T13670L	(Z)-Ligustilide	cis-Ligustilide,Ligustilide A	Antibacterial
	(Z)-Ligustilide (Ligustilide A) , an active ingredient isolated from the medicinal plants Angelica acutiloba and Cnidium officinale, inhibits benzo(a)pyrene-induced CYP1A1 upregulation in cultured human keratinocytes via...		Antibacterial

Natural Products

Xanthohumol

T3342

Synonym:

Target: Apoptosis, Others, Influenza Virus, COX, Acyltransferase, HSV

7beta-Methoxyrosmanol

7beta-(3-Ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone

Synonym: cis-Ligustilide,Ligustilide A

Target: Antibacterial

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-03004	Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His)	Mycobacterium tuberculosis	E. coli
	Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 34.1 kDa and the accession number is P9WQP2.
TMPH-03003	Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His & SUMO)	Mycobacterium tuberculosis	E. coli
	Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 44.6 kDa and the accession number is P9WQP2.
TMPH-03007	Ag85C Protein, Mycobacterium tuberculosis, Recombinant (His)	Mycobacterium tuberculosis	E. coli
	Ag85C Protein, Mycobacterium tuberculosis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 36.1 kDa and the accession number is P9WQN8.
TMPH-03005	Ag85B Protein, Mycobacterium tuberculosis, Recombinant (E. coli, His)	Mycobacterium tuberculosis	E. coli
	Ag85B Protein, Mycobacterium tuberculosis, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 36.2 kDa and the accession number is P9WQP0.
TMPH-03006	Ag85B Protein, Mycobacterium tuberculosis, Recombinant (His)	Mycobacterium tuberculosis	P. pastoris (Yeast)
	Ag85B Protein, Mycobacterium tuberculosis, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 32.7 kDa and the accession number is P9WQP0.