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PF-06424439

Catalog No. T12426   CAS 1469284-78-3

PF-06424439 is an oral and selective inhibitor of imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) (IC50 of 14 nM).

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PF-06424439 Chemical Structure
PF-06424439, CAS 1469284-78-3
Pack Size Availability Price/USD Quantity
5 mg 6-8 weeks $ 1,070.00
50 mg 6-8 weeks $ 2,180.00
100 mg 6-8 weeks $ 2,800.00
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage & Solubility Information
Description PF-06424439 is an oral and selective inhibitor of imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) (IC50 of 14 nM).
Targets&IC50 DGAT2:14 nM
In vivo PF-06424439 shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life[1].
Molecular Weight 439.94
Formula C22H26ClN7O
CAS No. 1469284-78-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

TargetMolReferences and Literature

1. Futatsugi K, et al. Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2). J Med Chem. 2015 Sep 24;58(18):7173-85. 2. Pabst B, et al. Mechanistic Characterization of Long Residence Time Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2). Biochemistry. 2018 Dec 26;57(51):6997-7010.

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PF-07202954 BMS-986172 24-Methylenecholesterol K-604 dihydrochloride OSMI-1 PF-04620110 PF-06424439 methanesulfonate RU-SKI 43

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Keywords

PF-06424439 1469284-78-3 Metabolism Acyltransferase Transferase Diglyceride acyltransferase mono- acylglycerol acyltransferase Inhibitor acyl-CoA:cholesterol acyltransferase Diacylglycerol acyltransferase PF06424439 inhibit PF 06424439 inhibitor

 

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