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PF-04620110

Catalog No. T6937 CAS 1109276-89-2

Synonyms: PF04620110, PF 04620110

PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.

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PF-04620110, CAS 1109276-89-2

Pack Size	Availability	Price/USD
2 mg	In stock	$ 37.00
5 mg	In stock	$ 57.00
10 mg	In stock	$ 106.00
25 mg	In stock	$ 208.00
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 99.82%

ee: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
Targets&IC50	DGAT-1:19 nM
In vitro	Ampiroxicam (<150 μM) dose-dependently decreases the proliferation of Panc-1 cells. [1] Ampiroxicam (50 μM) results in decreased expression of Sp1, Sp3, Sp4, and VEGFR1 proteins in Panc-1 cells and L3.6pl cells as determined by Western blot analysis. Ampiroxicam (50 μM) results in increased phosphorylation of MAPK1/2 in Panc-1 cells and L3.6pl cells. [2]
In vivo	In Rats, PF-04620110 reduces plasma triglyceride levels t doses of ≥0.1 mg/kg following a lipid challenge. [1] DGAT1 inhibition by PF-04620110 causes an enrichment of polyunsaturated fatty acids within the TG class of lipids in rodents. [2]

Synonyms	PF04620110, PF 04620110
Molecular Weight	396.44
Formula	C21H24N4O4
CAS No.	1109276-89-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7.9 mg/mL (20 mM)

References and Literature

1. Dow RL, et al. ACS Med Chem Lett. 2011, 2(5), 407-412. 2. Maciejewski BS, et al. Am J Physiol Gastrointest Liver Physiol. 2013, 304(11), G958-969.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Bioactive Compounds Library Max Clinical Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

Nevanimibe hydrochloride Glabrol PF-06424439 PF-07202954 RU-SKI 43 YM-750 BMS-986172 VULM 1457

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PF-04620110 1109276-89-2 Metabolism Acyltransferase Transferase acyl-CoA:cholesterol acyltransferase mono- acylglycerol acyltransferase PF04620110 Diacylglycerol acyltransferase Diglyceride acyltransferase PF 04620110 Inhibitor inhibit inhibitor

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