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Search Results for " ddr "

Targets

Discoidin Domain Receptor (DDR) Discoidin Domain Receptor (DDR)

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T10985	DDR Inhibitor		Discoidin Domain Receptor (DDR)
	DDR inhibitor is a potent discidin domain receptor (DDR) inhibitor. The IC50 of DDR2 is 3.3 nM, and DDR1 has 53% inhibition at 1.5 nM.		Discoidin Domain Receptor (DDR)
T10984	DDR-TRK-1		Discoidin Domain Receptor (DDR)
	DDR-TRK-1 is a selective discoid domain receptor 1 (DDR1) inhibitor with IC50 value of 9.4 nM. DDR-TRK-1 also inhibits the TRK family.		Discoidin Domain Receptor (DDR)
T31234	DDR-TRK-1N	DDR-TRK1N,DDRTRK-1N,DDRTRK1N,DDR-TRK 1N,DDR TRK-1N
	DDR-TRK-1N is a negative control for DDR-TRK-1.
T3337	Ddr1-In-1		Discoidin Domain Receptor (DDR)
	DDR1-IN-1 is an effective and specific DDR1 receptor tyrosine kinase inhibitor (IC50: 105 nM), about 3-fold selectivity over DDR2.		Discoidin Domain Receptor (DDR)
T5402	DDR1-IN-2	DDR1 inhibitor 7rh	Discoidin Domain Receptor (DDR)
	DDR1-IN-2 (DDR1 inhibitor 7rh) (DDR1 inhibitor 7rh) is a potent, selective, ATP-competitive Discoidin domain receptor 1 (DDR1) inhibitor (IC50: 6.8 nM in cell-free kinase assays).		Discoidin Domain Receptor (DDR)
T70201	S 16020-2
	S 16020-2 is an olivacine derivative, and DNA topoisomerase II inhibitor endowed with a remarkable antitumor activity against various experimental tumors.
T40062	DDR1-IN-5	DDR1-IN-5
	DDR1-IN-5 is a potent and selective inhibitor of the Discoidin Domain Receptor family, member 1 (DDR1). It effectively inhibits the phosphorylation of DDR1b (Y513) with an IC 50 value of 4.1 nM. Furthermore, DDR1-IN-5 de...
T39572	DDR1-IN-4	DDR1-IN-4
	DDR1-IN-4 (Compound 2.45) is a highly potent inhibitor that selectively targets Discoidin Domain Receptor 1 (DDR1) autophosphorylation. This compound demonstrates exceptional efficacy with IC50 values of 29 nM and 1.9 μM...
T39047	DDR2-IN-1	DDR2-IN-1
	DDR2-IN-1 (Compound 129) is recognized as a highly effective DDR2 inhibitor, displaying an IC50 value of 26 nM. It is a suitable choice for conducting osteoarthritis research.
T40061	DDR1-IN-6	DDR1-IN-6
	DDR1-IN-6 is a potent and selective inhibitor of Discoidin Domain Receptor family member 1 (DDR1), exhibiting remarkable inhibitory activity at an IC50 of 9.72 nM. It effectively suppresses the auto-phosphorylation of DD...
T11279	FGFR1/DDR2 inhibitor 1		Discoidin Domain Receptor (DDR) , FGFR , Others
	FGFR1/DDR2 inhibitor 1 is an inhibitor of discoindin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1 nM, 108.4 nM and 3.2 nM for FGFR1, KG-1, and DDR2, respectively.		Discoidin Domain Receptor (DDR) , FGFR , Others
T23974	DDRI-18	DDRI18,DDRI 18	DNA/RNA Synthesis
	DDRI-18 is a novel small molecule inhibitor that regulates the DNA damage response with sensitizing and anticancer activities, inhibits non-homologous end-joining (NHEJ) DNA repair and enhances the cytotoxicity of antica...		DNA/RNA Synthesis
T70202	DDR1-IN-1 dihydrochloride
	DDR1-IN-1 dihydrochloride is a selective and potent inhibitor of the DDR1 receptor tyrosine kinase, exhibiting an IC50 of 105 nM. It demonstrates fourfold reduced potency against DDR2, with an IC50 of 413 nM.
T79811	DDR1/2 inhibitor-2
	DDR1/2 Inhibitor-2 (Example 31) serves as an inhibitor of DDR1/DDR2, exhibiting IC50 values below 100 nM. It is applicable in cancer and fibrotic disease research [1].
T9117	BSJ-4-116		CDK , Ligand for E3 Ligase
	BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation).		CDK , Ligand for E3 Ligase
T60478	BTX161
	BTX161 is a Thalidomide analogue. BTX161 is a potent CKIα degrader. In human AML cells, BTX161 mediates the CKIα degradation better than Lenalidomide as well as activates DNA damage response (DDR) and p53, and also stabi...
T78959	ATR-IN-23		ATM/ATR
	ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility ...		ATM/ATR
T62651	ATR-IN-11
	ATR-IN-11 (Compound Hit01) is a potent inhibitor of ataxia capillaris and Rad3-related (ATR) kinases. ATR-IN-11 is a promising lead compound for the discovery of subsequent drugs targeting the ATR kinase, a key regulator...
T36701	Phosphoramide mustard (cyclohexanamine)
	Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA d...

Compounds

DDR Inhibitor

T10985

Synonym:

Target: Discoidin Domain Receptor (DDR)

DDR-TRK-1

T10984

Synonym:

Target: Discoidin Domain Receptor (DDR)

DDR-TRK-1N

T31234

Synonym: DDR-TRK1N,DDRTRK-1N,DDRTRK1N,DDR-TRK 1N,DDR TRK-1N

Target: Discoidin Domain Receptor (DDR)

DDR1-IN-2

T5402

Synonym: DDR1 inhibitor 7rh

Target: Discoidin Domain Receptor (DDR)

FGFR1/DDR2 inhibitor 1

T11279

Synonym:

Target: Discoidin Domain Receptor (DDR), FGFR, Others

DDRI-18

T23974

Synonym: DDRI18,DDRI 18

Target: DNA/RNA Synthesis

DDR1-IN-1 dihydrochloride

Target: CDK, Ligand for E3 Ligase

Phosphoramide mustard (cyclohexanamine)

T36701

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01289	DDR1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	DDR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is A0A024RCQ1.
TMPY-04382	DDR1 Protein, Human, Recombinant (aa 444-913, His & GST)	Human	Baculovirus Insect Cells
	DDR1 Protein, Human, Recombinant (aa 444-913, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 80 kDa and the accession number is Q08345-1.
TMPY-01751	DR3/TNFRSF25 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	DR3/TNFRSF25 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.
TMPK-00631	DR3/TNFRSF25 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	TNF-like ligand 1 A (TL1A) and death receptor 3 (DR3) are a ligand-receptor pair involved in the pathogenesis of inflammatory bowel disease. Group 3 innate lymphoid cells (ILC3s) regulate intestinal immunity and highly e...
TMPY-05760	DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated	Human	HEK293 Cells
	DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.
TMPY-03642	DDR2 Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293 Cells
	DDR2 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 7.0 kDa and the accession number is XP_001118219.1.
TMPY-00773	DDR2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	DDR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69.4 kDa and the accession number is Q16832.
TMPY-02310	DDR1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	DDR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.4 kDa and the accession number is Q03146-1.
TMPY-03593	DDR2 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293 Cells
	DDR2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.1 kDa and the accession number is XP_001118219.1.
TMPH-01297	DDR1 Protein, Human, Recombinant (aa 21-417, His)	Human	HEK293 Cells
	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival ...
TMPY-03166	DDR2 Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	DDR2 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.9 kDa and the accession number is B1WC09.
TMPY-03625	DDR2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	DDR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.1 kDa and the accession number is Q16832.
TMPY-04442	DDR1 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus Insect Cells
	DDR1 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75.8kDa and the accession number is Q03146-2.
TMPY-04361	DDR2 Protein, Human, Recombinant (aa 422-855, His & GST)	Human	Baculovirus Insect Cells
	DDR2 Protein, Human, Recombinant (aa 422-855, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 77.1 kDa and the accession number is Q16832.
TMPY-01728	DDR2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	DDR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.88 kDa and the accession number is Q62371.
TMPY-03098	DDR2 Protein, Rat, Recombinant (hFc)	Rat	HEK293 Cells
	DDR2 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69.5 kDa and the accession number is B1WC09.
TMPY-02506	DDR1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	DDR1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71 kDa and the accession number is Q03146-1.
TMPY-03313	DDR1 Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	DDR1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.3 kDa and the accession number is Q6MG19.
TMPY-03541	DDR1 Protein, Rat, Recombinant (hFc)	Rat	HEK293 Cells
	DDR1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 70.9 kDa and the accession number is Q6MG19.