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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10970 | DC1 | Others | |
DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer, is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065. | |||
T9978 | Glutathione synthesis-IN-1 | Others | |
Glutathione synthesis-IN-1 (DC-1) is a inhibitor of glutathione synthesis[1]. | |||
T15080 | DC-05 | DNA Methyltransferase , Histone Methyltransferase | |
DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively). | |||
T73288 | DC-BPi-03 | ||
DC-BPi-03 is a potent BPTF-BRD inhibitor with an IC 50 of 698.3 nM and a K d of 2.81 μM . | |||
T41257 | SJ6986 | Others | |
SJ6986 is a potent, selective and orally active GSPT1/2 degrader. SJ6986 degrades GSPT1 with a DC 50 of 2.1 nM (D max 99%) [1]. | |||
T5S0761 | Nitidine chloride | Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite | |
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id... | |||
T70537 | DC 015 | ||
DC 015 is a novel potent and selective alpha 1-adrenoceptor antagonist. | |||
T74796 | PROTAC GPX4 degrader-1 | ||
PROTAC GPX4 Degrader-1 (DC-2) is a PROTAC-based compound that efficiently degrades GPX4, demonstrating a degradation concentration (DC 50) of 0.03 μM in HT1080 cells [1]. | |||
T36754 | DMT-dC(bz) Phosphoramidite | ||
DMT-dC(bz) Phosphoramidite is typically used in the synthesis of DNA[1]. | |||
T61314 | DC-CPin7 | ||
DC-CPin7, a powerful inhibitor of the bromodomain of CREB-binding protein (CBP), exhibits an IC50 value of 2.5 μM [1]. | |||
T63859 | DNMT3A-IN-1 | ||
DNMT3A-IN-1 is a selective and potent DNMT3A inhibitor. DNMT3A-IN-1 exhibits inhibitory activity against DNMT3A with a KI ranging from 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC). | |||
T61871 | DC-LC3in-D5 | ||
DC-LC3in-D5 is a chemical compound that functions as an autophagy inhibitor by diminishing the process of LC3B lipidation. It forms a binding association with LC3B, disrupting the LC3B-LBP2 interaction with an IC50 of 20... | |||
T61719 | DC-CPin711 | ||
DC-CPin711, a potent and selective inhibitor of the bromodomain of CREB-binding protein (CBP) with an IC50 of 0.0626 μM, effectively halts the cell cycle at the G1 phase and promotes apoptosis [1]. | |||
T78142 | DC-BPi-11 hydrochloride | Epigenetic Reader Domain | |
DC-BPi-11 hydrochloride is a BPTF (bromodomain PHD finger transcription factor) inhibitor with an IC50 value of 698 nM, demonstrating significant anti-proliferative effects on leukemia cells [1]. | |||
T75269 | DMT-5Me-dC(Bz)-CE Phosphoramidite | ||
DMT-5Me-dC(Bz)-CE Phosphoramidite is utilized in synthesizing locked nucleic acids (LNAs) to enhance fluorescent oligonucleotide probes by optimizing their spectral properties and target affinity [1]. | |||
T83949 | DC 432 | ||
DC 432, a potent peptidomimetic inhibitor of N-terminal methyltransferase 1/2 (NTMT1/2) with an IC50 value of 54 nM, incorporates a BM30 peptide enhanced by five arginine residues. It effectively reduces the N-terminal m... | |||
T81348 | PTZ-LD | ||
PTZ-LD, a phenothiazine-based fluorescent probe, specifically detects lipid droplets (LDs) with apparent emissivity (Ex/Em=488/570-620 nm) and is utilized in diabetic cataract (DC) research [1]. | |||
T75190 | 5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite | ||
5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies. Its anticancer efficacy stems from the inhibition of DNA synt... | |||
T75226 | Rev dC(Bz)-5'-amidite | ||
Rev dC(Bz)-5'-amidite is a purine nucleoside analog exhibiting extensive antitumor efficacy, particularly against indolent lymphoid malignancies. Its anticancer mechanisms are primarily mediated through the inhibition of... | |||
T37147 | 5'-O-DMT-N4-Ac-dC | 5'-O-DMT-N4-Ac-dC | |
5'-O-DMT-N4-Ac-dC (N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine, compound 7) is a deoxynucleoside utilized in the synthesis of dodecyl phosphoramidite. Dodecyl phosphoramidite serves as a crucial precursor for dod-DNA production... |