chk2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2033	BML-277	C 3742,Chk2 Inhibitor II,BML 277	Apoptosis , Chk
	BML-277 (C 3742) is a selective checkpoint kinase 2 (Chk2) inhibitor.		Apoptosis , Chk
T6028	PF 477736	PF 00477736,PF-477736,PF-736,PF-00477736,PF477736	c-Fms , VEGFR , FGFR , FLT , c-RET , Chk , CDK , Src , Aurora Kinase
	PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
T10718L	CCT241533 hydrochloride		Chk
	CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).		Chk
T71259	GNE-900	GNE900,GNE 900	Apoptosis , Chk
	GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 ...		Apoptosis , Chk
T3700	SCH900776 (S-isomer)	MK-8776 S-isomer,SCH900776 S-isomer	Chk , CDK
	SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM). It also inhibitors Chk2 (IC50: 1500 nM) and cyclin-dependent kinase CDK2 (IC50: 16...		Chk , CDK
T4327	Prexasertib dihydrochloride	LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368	Apoptosis , Chk , S6 Kinase
	Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.		Apoptosis , Chk , S6 Kinase
T13148	CHK-IN-1		Chk
	CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.		Chk
T7080	CCT245737	SRA737	Chk
	CCT245737 (SRA737) is an orally active and selective Chk1 inhibitor (IC50: 1.3 nM); CCT245737 shows much less activity against Chk2 (IC50: 2440 nM).		Chk
T6350	CHIR-124	CHIR124,CHIR 124	Apoptosis , GSK-3 , FLT , Chk , PDGFR , Src
	CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.		Apoptosis , GSK-3 , FLT , Chk , PDGFR , Src
T6093	AZD-7762	AZD7762	Chk
	AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.		Chk
T6940	PHA-767491 hydrochloride	CAY10572,PHA-767491,PHA767491 HCl,CAY-10572 hydrochloride	Apoptosis , GSK-3 , CDK
	PHA-767491 hydrochloride (CAY-10572 hydrochloride) is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against GSK3-β and CDK1/2, 50-fold selectivity against CDK5 and MK...		Apoptosis , GSK-3 , CDK
T2517	SCH900776	MK 8776,MK-8776	Chk , CDK
	SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.		Chk , CDK
T21331	SAR-020106		Chk
	SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.		Chk
T17223	VER-00158411		Chk
	VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).		Chk
T36704	CCT241533 dihydrochloride	CCT 241533 dihydrochloride
	Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radi...
T4310	Prexasertib	LY2606368	Apoptosis , Chk
	Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.		Apoptosis , Chk
T10718	CCT241533		Chk
	CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).		Chk
T73411	PV-1019	NSC 744039
	PV-1019 (NSC 744039) is a potent, selective inhibitor of Chk2, displaying an IC50 of 24 nM. It effectively inhibits Topotecan-induced Chk2 autophosphorylation and suppresses IR-induced apoptosis [1].
T24688	PV-1115	PV1115
	PV-1115 is an effective and highly selective inhibitor of the Chk2.
T23089	NSC 109555 ditosylate		Others
	Chk2 inhibitor,ATP-competitive		Others