cyp1a1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T27109	CYP1A1 inhibitor 8a
	CYP1A1 inhibitor 8a is a potent and selective CYP1A1 inhibitor. It antagonizes B[a]P mediated activation of aromatic hydrocarbon receptor (AhR) in yeast cells, thereby protects human cells from CYP1A1-mediated B[a]P toxi...
T5116	Iprodione		Others , Reactive Oxygen Species , Antifungal
	Iprodione is a fungicide. Iprodione is also used in cannabis testing kits as a component of pesticide mixes.		Others , Reactive Oxygen Species , Antifungal
T8198	Visnagin		Others
	Visnagin has acute hypotensive, anti-inflammatory, and neuroprotective effects, it protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase.		Others
T10270	BAY 2416964		Aryl Hydrocarbon Receptor
	BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist(example 192, IC50: 341 nM). It has the potential for cancer treatment.		Aryl Hydrocarbon Receptor
T5786	TETRAHYDROPIPERINE	Cosmoperine	P450 , TRP/TRPV Channel
	Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.		P450 , TRP/TRPV Channel
T8729	3-(2-Naphthalenyl)-1-(3-pyridinyl)-2-propen-1-one		P450
	DMU2105 is a specific CYP1B1 inhibitor(CYP1B1 and CYP1A1 with IC50 of 10 nM and 742 nM, respectively)		P450
T9328	Ellagic Acid Dihydrate		P450
	Ellagic Acid Dihydrate inhibit the CYP1A1-dependent activation of benzo[a]pyrene.		P450
T2949	Alizarin	Mordant Red 11,Anthraquinonic	P450
	Alizarin (Mordant Red 11), a red dye derived from the roots of plants of the madder genus, inhibits P450 isoform CYP1A1( IC50 = 6.2 μM), CYP1A2 (IC50 =10.0 μM )and CYP1B1(IC50 = 2.7 μM).		P450
T8728	DMU-2139		P450
	DMU2139 is a specific CYP1B1 inhibitor (CYP1B1 and CYP1A1 with IC50 of 9 nM and 795 nM, respectively).		P450
T3585	TMS	(E)-2,3',4,5'-tetramethoxystilbene,2,3',4,5'-Tetramethoxystilbene	P450
	TMS (2,3',4,5'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).		P450
T23151	Phortress	NSC 710305	AhR
	Phortress (NSC-710305) is a potent AhR ligand with strong binding affinity, which subsequently triggers the transcription of CYP1A1 and induces antitumor activity.		AhR
T7472	7-Hydroxyflavone		P450
	7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2.with anti-inflammatory activity		P450
T5S0669	Bergamottin	5-Geranoxypsoralen,Bergamotine,Bergaptin	P450
	1. Bergamottin (5-Geranoxypsoralen) can significantly reduce blood glucose and increase glucose tolerance and insulin sensitivity in KK-A^ydiabetic mice.		P450
T3668	Galangin	Norizalpinin,3,5,7-Trihydroxyflavone	ERK , P450 , NF-κB , Autophagy
	Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.		ERK , P450 , NF-κB , Autophagy
T21507	7-Ethoxyresorufin	Resorufin ethyl ether	P450 , NO Synthase
	7-Ethoxyresorufin (Resorufin ethyl ether) (7-ER) is a fluorometric substrate for and competitive inhibitor of cytochrome P450, especially CYP1A1.		P450 , NO Synthase
T7696	3-Cyano-7-ethoxycoumarin		Others
	3-Cyano-7-ethoxycoumarin is cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 .		Others
T3158L	Harman hydrochloride	Harmane hydrochloride(486-84-0 Free base)	P450
	Harman hydrochloride can directly induce CYP1A1 gene expression in an AhR-dependent manner and may represent a novel mechanism by which harman promotes mutagenicity, co-mutagenicity and carcinogenicity.		P450
T11218	ε-Viniferin	epsilon-Viniferin	P450
	ε-Viniferin (epsilon-Viniferin) a dimer of resveratrol, shows the inhibitory effects of epsilon-viniferin on human CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2E1, CYP3A4 and CYP4A activities.		P450
T21704	5-fluoro 203	5F-203,NSC-703786	Others
	5-fluoro 203 (NSC-703786) is a cytotoxic molecule leading to cell death by forming DNA adducts. 5-fluoro 203 induces aryl hydrocarbon receptor signaling, and elevates expression of CYP1A1. 5-fluoro 203 treatment of cells...		Others
T7088	Diflubenzuron	Dimilin,Difubenzuron,Larvakil,Difluron	P450
	Diflubenzuron (Larvakil) is a benzoyl-urea insecticide, found to be a potent inhibitor of melanosome synthesis in mouse melanoma cells. Diflubenzuron has also been shown to inhibit TCDD-induced CYP1A1 expression in HepG2...		P450