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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10894 | CSF1R-IN-1 | c-Fms | |
CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM. | |||
T13194 | CSF1R-IN-2 | c-Fms , c-Met/HGFR , Src | |
CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively). | |||
T2500 | Cediranib | AZD2171,NSC-732208 | VEGFR , FLT , PDGFR , c-Kit , Autophagy |
Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/≤3 nM), similar activity against PDGFRβ and c-Kit... | |||
T2624 | OSI-930 | OSI 930 | Apoptosis , c-Fms , Raf , VEGFR , FLT , CSF-1R , Src , c-Kit |
OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel growth (angiogenesis) in tumors. | |||
T10647 | C-Fms-IN-8 | CSF-1R | |
c-Fms-IN-8 is a colony-stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor (IC50: 9.1 nM). It is compound 4a in the reference. | |||
T10644 | C-Fms-IN-10 | Others | |
c-Fms-IN-10 is the derivative of thieno [3,2-d] pyrimidine, a kinase inhibitor of FMS (Colony-stimulating factor-1 receptor, CSF-1R; IC50: 2 nM) with anti-tumor activity. | |||
T76868 | Lacnotuzumab | ||
Lacnotuzumab (MCS110), a humanized IgG1/κ monoclonal antibody, neutralizes and inhibits the interaction between CSF-1 and its receptor, CSF-1R. It is utilized in researching pigmented villonodular synovitis [1] [2]. | |||
T62187 | CSF1R-IN-6 | ||
CSF1R-IN-6 is a potent inhibitor of CSF1R. CSF1R-IN-6 is a potent inhibitor of CSF1R, which is expressed in macrophages and is dependent on the CSF-1/CSF-1R signalling pathway for survival and differentiation of macropha... | |||
T62342 | CSF1R-IN-4 | ||
CSF1R-IN-4 is a potent inhibitor of CSF-1R. CSF1R-IN-4 can affect the exchange of inflammatory factors between TAM and glioma cells. CSF1R-IN-4 has potential for the study of cancer diseases. EGFR-IN-40. | |||
T76915 | Axatilimab | ||
Axatilimab (SNDX-6352), a humanized IgG4 antibody that binds with high affinity to CSF-1R, is utilized in the study of chronic graft versus host disease (cGVHD) and various neoplastic diseases [1] [2]. | |||
T62364 | CSF1R-IN-5 | ||
CSF1R-IN-5 is a potent inhibitor of CSF1R. CSF1R-IN-5 can affect the exchange of inflammatory factors between TAM and glioma cells. CSF1R-IN-5 has the potential to be used in the study of cancer diseases. |