creb — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5318	666-15	CREB inhibitor	Epigenetic Reader Domain
	666-15 (CREB inhibitor) is a potent and selective CREB inhibitor (IC50: 81 nM).		Epigenetic Reader Domain
T64247	CREB-IN-1 TFA
	CREB-IN-1 TFA is a potent, orally active CREB inhibitor with an IC50 value of 0.18 μM. CREB-IN-1 TFA exhibits inhibitory effects on the growth of breast cancer cells.
T72227	PI3K/Akt/CREB activator 1
	PI3K/Akt/CREB Activator 1 is a potent, orally active compound that acts as an activator for the PI3K/Akt/CREB pathway. It enhances neuronal proliferation, induces differentiation of Neuro-2a cells into neuron-like morpho...
T8890	653-47 hydrochloride		Epigenetic Reader Domain
	653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. It is also a very weak CREB inhibitor with IC50 of 26.3 μM.		Epigenetic Reader Domain
T7856	Naphthol AS-E	nAS-E	Epigenetic Reader Domain , Histone Acetyltransferase
	Naphthol AS-E (nAS-E) is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.		Epigenetic Reader Domain , Histone Acetyltransferase
TP1876L	CREBtide acetate(149155-45-3 free base)		PKA
	CREBtide acetate is a synthetic substrate for PKA (Km=3.9 μM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).		PKA
T27083	Crebinostat		Epigenetic Reader Domain , Histone Acetyltransferase , HDAC
	Crebinostat is a potent histone deacetylase (HDAC) inhibitor, inhibiting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respectively.Crebinostat increases the density of synapsin-1 punct...		Epigenetic Reader Domain , Histone Acetyltransferase , HDAC
T2S2215	Crebanine		Apoptosis , Others , Akt
	1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rat...		Apoptosis , Others , Akt
TP1876	CREBtide
	CREBtide is a synthetic substrate for PKA (Km=3.9 µM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).
T27082	CREBBP-IN-9	CREBBPIN9,CREBBP IN 9
	CREBBP-IN-9, a CREBBP inhibitor, acts on the bromodomain of the protein.
TN3799	Dehydrocrebanine		Antifection
	Dehydrocrebanine has strong activity against promyelocytic leukemia cells (HL-60) with an IC50 of 2.14 ug/mL. It also shows potent antimalarial activity with an IC50 value of 70 ng/ml.		Antifection
T81587	Oxocrebanine
	Oxocrebanine, an aporphine alkaloid present in Fissistigma poilanei (Annonaceae) [1], is identified as a constituent of this botanical species.
T73920	Ep300/CREBBP-IN-8
	Ep300/CREBBP-IN-8 (Example 37), a potent and orally active inhibitor of both Ep300 and CREBBP, exhibits IC50 values of 0.014 μM and 0.018 μM, respectively. This compound is utilized in cancer research [1].
T126510	Crebanine N-oxide
	Crebanine N-oxide is a useful organic compound for research related to life sciences. The catalog number is T126510 and the CAS number is 102719-85-7.
T73923	Ep300/CREBBP-IN-4
	Ep300/CREBBP-IN-4 (Example 56), a highly effective inhibitor targeting both Ep300 and CREBBP, exhibits IC50 values of 0.024 μM and 0.064 μM, respectively. This compound is utilized in cancer research [1].
T29025	Tylocrebrine	NSC-60387,NSC60387,NSC 60387,Tylocrebrinel
	Tylocrebrine is anticancer agent.
T73922	Ep300/CREBBP-IN-3
	Ep300/CREBBP-IN-3 (Example 61), a potent inhibitor of Ep300 and CREBBP, exhibits IC50 values of 0.056 μM and 0.095 μM, respectively. This compound is applicable in cancer research [1].
T73921	Ep300/CREBBP-IN-2
	Ep300/CREBBP-IN-2 (Example 73), a powerful and orally bioavailable inhibitor targeting Ep300 and CREBBP, demonstrates IC50 values of 0.052 μM and 0.148 μM, respectively. This compound is employed in cancer research [1].
T7297	KG-501	Naphthol AS-E phosphate	Epigenetic Reader Domain
	KG-501 (Naphthol AS-E phosphate) is a cAMP response element-binding protein (CREB) inhibitor(IC50 : 6.89 μM).		Epigenetic Reader Domain
T24212	XX-650-23	XX65023,XX 650 23	Apoptosis , Epigenetic Reader Domain
	XX-650-23 is a small molecule CREB inhibitor that blocks the critical interaction between CREB and its required coactivator, CBP (CREB-binding protein), inducing apoptosis and cell cycle arrest in AML cells, and can be u...		Apoptosis , Epigenetic Reader Domain