Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CREBtide acetate is a synthetic substrate for PKA (Km=3.9 μM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 75.00 | |
5 mg | In stock | $ 261.00 | |
10 mg | In stock | $ 410.00 | |
25 mg | In stock | $ 683.00 | |
50 mg | In stock | $ 973.00 | |
100 mg | In stock | $ 1,290.00 | |
500 mg | In stock | $ 2,630.00 |
Description | CREBtide acetate is a synthetic substrate for PKA (Km=3.9 μM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein). |
In vitro | delta-CREB is a spliced variant of cAMP response element binding protein (CREB). CREBtide (KRREILSRRPSYR), a synthetic peptide based on the phosphorylation sequence in delta-CREB. delta-CREB and CREBtide are tested as substrates of cAMP-dependent protein kinase (cAK). The apparent Km of CREBtide phosphorylation by cAK is 3.9 μM, which is 10-fold lower than that of Kemptide (Km=39 μM), the synthetic peptide substrate most often employed for cAK measurement. The Vmax values are 12.4 mumol/(min.mg) for CREBtide and 9.8 mumol/(min.mg) for Kemptide. The apparent Km of CREBtide phosphorylation by cGMP-dependent protein kinase (cGK) is 2.9 μM and the Vmax value is 3.2 mumol/(min.mg). Both delta-CREB and CREBtide are phosphorylated at a much slower rate by cGK as compared with cAK, implying that the high cAK/cGK specificity exhibits by delta-CREB is retained by the peptide[2]. |
Molecular Weight | 1777.07 |
Formula | C75H133N29O21 |
CAS No. | TP1876L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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CREBtide acetate(149155-45-3 free base) TP1876L Tyrosine Kinase/Adaptors PKA CREBtide acetate(149155 45 3 free base) CREBtide acetate(149155453 free base) inhibitor inhibit