comt — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T60658	HMAO-B/MB-COMT-IN-2
	hMAO-B/MB-COMT-IN-2 is a dual inhibitor of MAO-B/MB-COMT with IC 50s of 4.27 μΜ and 2.69 μΜ for hMAO-B and MB-COMT, respectively. hMAO-B/MB-COMT-IN-2 protects cells from oxidative damage that can be used in the neurodege...
T60489	HMAO-B/MB-COMT-IN-1
	hMAO-B/MB-COMT-IN-1 is a dual MAO-B/MB-COMT inhibitor with IC50s of 2.5 μΜ for hMAO-B and 3.84 μΜ for MB-COMT. hMAO-B/MB-COMT-IN-1 protects cells from oxidative damage that can be used in neurodegeneration disease resear...
T16398	Opicapone	BIA 9-1067	Transferase
	Opicapone (BIA 9-1067) reduces the ATP content of the cells (IC50: 98 μM). Opicapone is an effective third-generation catechol-O-methyltransferase inhibitor for the research of Parkinson's disease and motor fluctuations.		Transferase
T7831	Nitecapone		Others , Transferase
	Nitecapone is a reversible inhibitor of S-COMT (IC50 values of 300 nM in rat liver)		Others , Transferase
T0525	Flopropione	Phloropropiophenone	5-HT Receptor , Transferase
	Flopropione (Phloropropiophenone), a spasmolytic or antispasmodic agent, is used as a 5-HT1A receptor antagonist.		5-HT Receptor , Transferase
T2216	Entacapone	OR-611	Transferase
	Entacapone (OR-611) is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT).		Transferase
T2765	Rosmarinic acid	Labiatenic acid,Rosemary acid	Apoptosis , IκB/IKK , MAO , Endogenous Metabolite , Transferase , Monoamine Oxidase
	Rosmarinic acid (Labiatenic acid) is widely found in plants and has antioxidant, anti-inflammatory, and antibacterial activities. It inhibits MAO-A, MAO-B, and COMT with IC50 of 50.1, 184.6, and 26.7 μM respectively.
T6708	Tolcapone	Tasmar,Ro 40-7592	Apoptosis , Beta Amyloid , Transferase
	Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa.		Apoptosis , Beta Amyloid , Transferase
TN2437	Serotonin	5-hydroxytryptamine,5-HT	Others , 5-HT Receptor , Endogenous Metabolite , Transferase
	Serotonin (5-hydroxytryptamine) is a natural product from animals
T4983	Isoetharine mesylate salt	Isoetarine mesilate	Others , Adrenergic Receptor
	Isoetharine mesylate salt (Isoetarine mesilate) is a β-adrenergic receptor agonist. it also is pregnane X receptor (PXR) activator capable of upregulating CYP450 expression.		Others , Adrenergic Receptor
T2209	Serotonin hydrochloride	5-HT hydrochloride,5-HT HCl,Serotonin HCl,5-Hydroxytryptamine hydrochloride	5-HT Receptor , Endogenous Metabolite , Transferase
	Serotonin hydrochloride (Serotonin HCl) is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM).		5-HT Receptor , Endogenous Metabolite , Transferase
T23109	3,5-Dinitrocatechol		Transferase
	OR-486 is an inhibitor of catechol-O-methyl-transferase(COMT) and can be used to prepare the molybdenum (VI)- 3,5-Dinitrocatechol complex.		Transferase
TN7057	Rosmarinate acid	(R)-rosmarinic acid,rosmarinic acid,Rosemary acid	MAO , Endogenous Metabolite , Transferase
	Rosmarinate acid(Rosemary acid) inhibits MAO-A, MAO-B and COMT enzymes with IC50s of 50.1, 184.6 and 26.7 μM, respectively		MAO , Endogenous Metabolite , Transferase
T24030	Entacapone acid	AG1290,AG 1290,AG-1290	Transferase
	Entacapone acid (AG 1290) is a selective and reversible inhibitor of catechol-O-methyltransferase(COMT).		Transferase
T11207	Entacapone sodium salt		Others
	Entacapone sodium salt inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. Entacapo...		Others
T26106	Ro 41-0960	Ro-41-0960,Ro41-0960
	Ro 41-0960 is used as a reversible and orally-active COMT-inhibitor.
T75389	Catechol O-methyltransferase
	Catechol O-methyltransferase (COMT) is a magnesium-dependent enzyme that mediates the transfer of methyl groups from S-adenosyl methionine to the hydroxyl group on dopamine, thus converting it to 3-methoxytyramine. COMT ...
T16279	Nebicapone	BIA 3-202	Others
	Nebicapone is a reversible catechol-O-methyltransferase (COMT) inhibitor and is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to ...		Others
T9455	4-hydroxyestrone-4-methyl ether	4-Methoxy Estrone	Estrogen Receptor/ERR , Endogenous Metabolite
	4-hydroxyestrone-4-methyl ether (4-Methoxy Estrone) is the methylation of 4-OHE1, which is catalyzed by COMT.		Estrogen Receptor/ERR , Endogenous Metabolite
T27162	DHMPA
	DHMPA is an inhibitor of catechol-O-methyltransferase (COMT), it also reduces tissue norepinephrine and blood pressure.