Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OR-486 is an inhibitor of catechol-O-methyl-transferase(COMT) and can be used to prepare the molybdenum (VI)- 3,5-Dinitrocatechol complex.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 54.00 | |
10 mg | In stock | $ 77.00 | |
25 mg | In stock | $ 125.00 | |
50 mg | In stock | Inquiry |
Description | OR-486 is an inhibitor of catechol-O-methyl-transferase(COMT) and can be used to prepare the molybdenum (VI)- 3,5-Dinitrocatechol complex. |
Targets&IC50 | COMT:12 nM |
In vitro | OR-486 is highly effective (IC50 = 12 nM) and selective in inhibiting COMT activity in vitro[3]. |
In vivo | In mouse trachea (β1-AR dominant), significant suppression of ISO-induced relaxation was observed with the addition of OR-486. In GP trachea, in the presence of clorgiline plus OR-486, both normetadrenaline (NMA) and metadrenaline (MA) (10-4 M) significantly suppressed ISO-induced relaxation[1]. |
Molecular Weight | 200.11 |
Formula | C6H4N2O6 |
CAS No. | 7659-29-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 20.01 mg/mL
DMSO: < 20.01 mg/mL
H2O: 0.17 mg/mL
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
3,5-Dinitrocatechol 7659-29-2 Metabolism Transferase inhibit 3,5-Dinitropyrocatechol 3,5Dinitrocatechol molybdenum OR486 3,5 Dinitrocatechol OR 486 Inhibitor OR-486 inhibitor