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3,5-Dinitrocatechol

Catalog No. T23109   CAS 7659-29-2

OR-486 is an inhibitor of catechol-O-methyl-transferase(COMT) and can be used to prepare the molybdenum (VI)- 3,5-Dinitrocatechol complex.

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3,5-Dinitrocatechol Chemical Structure
3,5-Dinitrocatechol, CAS 7659-29-2
Pack Size Availability Price/USD Quantity
5 mg In stock $ 54.00
10 mg In stock $ 77.00
25 mg In stock $ 125.00
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Purity: 99.88%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description OR-486 is an inhibitor of catechol-O-methyl-transferase(COMT) and can be used to prepare the molybdenum (VI)- 3,5-Dinitrocatechol complex.
Targets&IC50 COMT:12 nM
In vitro OR-486 is highly effective (IC50 = 12 nM) and selective in inhibiting COMT activity in vitro[3].
In vivo In mouse trachea (β1-AR dominant), significant suppression of ISO-induced relaxation was observed with the addition of OR-486. In GP trachea, in the presence of clorgiline plus OR-486, both normetadrenaline (NMA) and metadrenaline (MA) (10-4 M) significantly suppressed ISO-induced relaxation[1].
Molecular Weight 200.11
Formula C6H4N2O6
CAS No. 7659-29-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 20.01 mg/mL

DMSO: < 20.01 mg/mL

H2O: 0.17 mg/mL

TargetMolReferences and Literature

1. Yamaki F, et, al. Effects of Catecholamine Metabolites on Beta-Adrenoceptor-Mediated Relaxation of Smooth Muscle: Evaluation in Mouse and Guinea-Pig Trachea and Rat Aorta. Biol Pharm Bull. 2020;43(3):493-502. 2. Stojnova K, et, al. Study on the Complex Equilibria of Molybdenum(VI) with 3,5-Dinitrocatechol and Ditetrazolium Salt. Acta Chim Slov. 2016;63(3):654-60. 3. Nissinen E, et, al. Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat. Eur J Pharmacol. 1988 Aug 24;153(2-3):263-9.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Inhibitor Library Metabolism Compound Library Bioactive Compound Library Human Metabolite Library

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Keywords

3,5-Dinitrocatechol 7659-29-2 Metabolism Transferase inhibit 3,5-Dinitropyrocatechol 3,5Dinitrocatechol molybdenum OR486 3,5 Dinitrocatechol OR 486 Inhibitor OR-486 inhibitor

 

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