atx — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10409	ATX inhibitor 5		PDE
	ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50 : 15.3 nM) that reduces the level of CCl4-induced hepatic fibrosis and has anti-hepatic fibrosis effects,.		PDE
T10410	ATX inhibitor 1		PDE
	ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).		PDE
T39190	ATX-002
	ATX-002 is a property-tunable lipid for RNA drug delivery.
T39136	ATX inhibitor 7
	ATX inhibitor 7 is a autotaxin inhibitor and shows good oral exposure.
T80039	ATX-II		Sodium Channel
	ATX-II, an Na+ channel modulator toxin derived from the sea anemone (Anemonia sulcata), causes delayed inactivation of the Na+ channels and has been linked to pulmonary vein arrhythmogenesis and atrial fibrillation [1] [...		Sodium Channel
T61612	ATX inhibitor 15
	ATX inhibitor 15 (compound 30) is an indole-based carbamate derivative with a strong inhibitory effect on autotaxin (ATX), demonstrated by an IC50 of 2.17 nM. Additionally, ATX inhibitor 15 effectively inhibits ATX activ...
T64141	ATX inhibitor 11
	ATX inhibitor 11 is a potent inhibitor of ATX (autotaxin) (IC50: 2.7 nM). ATX inhibitor 11 alleviates the severity of fibrotic tissue and effectively reduces the deposition of α-SMA, a biomarker of fibrosis, in a mouse m...
T63325	ATX inhibitor 9
	ATX inhibitor 9 is a thickened heteroaryl derivative compound and a potent inhibitor of ATX. Among them Autotaxin (ATX), also known as ENPP2, is a secreted enzyme highly expressed mainly in lung cancer cells, bronchial e...
T82936	ATX-II TFA		Sodium Channel
	ATX-II TFA, a specific Na+ channel modulator toxin, is derived from the venom of the sea anemone (Anemonia sulcata). This compound impedes the inactivation of Na+ channels and has been associated with arrhythmogenesis in...		Sodium Channel
T63904	ATX inhibitor 19
	ATX inhibitor 19 is a potent inhibitor of ATX (IC50: 156 nM).
T72681	ATX inhibitor 17
	ATX inhibitor 17, a powerful ATX inhibitor, exhibits an IC50 value of 0.019 µM, demonstrating significant anti-proliferative effects in breast cancer cells.
T64210	ATX inhibitor 13
	ATX inhibitor 13 (compound 10c) is an orally active ATX inhibitor (IC50: 3.4 nM). ATX inhibitor 13 is capable of blocking the cell cycle of RAW264.7 cells in the G2 phase, inhibiting cell proliferation and migration and ...
T63584	ATX inhibitor 12
	ATX inhibitor 12 is an orally active ATX inhibitor (IC50: 1.72 nM). In C57Bl/6J mice, oral administration of ATX inhibitor 12 at a dose of 60 mg/kg was effective in inhibiting structural lung damage and reducing fibrotic...
T63845	ATX inhibitor 14
	ATX inhibitor 14, an indole-based carbamate derivative, is a potent inhibitor (IC50: 0.41 nM) of self-adhesive proteins (ATX) and has shown potential for research in fibrosis-related diseases.
T63510	ATX inhibitor 21
	ATX inhibitor 21 is a potent inhibitor of ATX (IC50: 3490 nM).
T63829	ATX inhibitor 20
	ATX inhibitor 20 is a potent inhibitor of ATX (IC50: 2.3 nM).
T63524	ATX inhibitor 10
	ATX inhibitor 10 is a nitrogen-containing heterocyclic compound that is a potent inhibitor of ATX. Among other things, ATX plays a role in causing pathologies including fibrosis, neurodegeneration, arthritis, neuropathic...
T63612	ATX inhibitor 8
	ATX inhibitor 8 is an inhibitor of the autocrine motor factor Autotaxin (ATX).
T64130	ATX inhibitor 16
	ATX inhibitor 16 is a potent inhibitor of ATX (IC50: 0.0021 μM). ATX inhibitor 16 exhibits a significant anti-proliferative effect on breast cancer cells.
T63564	ATX inhibitor 22
	ATX inhibitor 22 is a novel inhibitor of ATX (autotaxin) (IC50: 218.9 μM) that lacks inhibitory activity against LPAR1.
T27324	FK614	FK 614,ATx-08-001,ATx-08001,FK-614
	FK-614 is a selective agonist of peroxisome proliferator-activated receptor gamma. FK-614 improves peripheral glucose utilization while decreases hepatic insulin extraction in alloxan-induced diabetic dogs.
T31101	CRT0273750	CRT 0273750,CRT-0273750	PDE
	CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.		PDE
T11533	Z-HA155	CS-963	PDE
	Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.		PDE
TP2027	GaTx2
	Very high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and...
T38759	ONO-8430506		PDE
	ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.		PDE
T2646	HA130		PDE
	HA130 is a selective ATX (autotaxin) inhibitor.		PDE
T22086	HA 155	Autotaxin Inhibitor IV	PDE
	HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.		PDE
T10545	BIO-32546		PDE
	BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.		PDE
T4041	Ziritaxestat	GLPG1690	PDE
	Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.		PDE
T10415	Autotaxin-IN-3		PDE
	Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma.		PDE
T3631	PF-8380		PDE
	PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood). It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhib...		PDE
T14560	BI-2545		Others
	BI-2545 is an autotaxin (ATX) inhibitor that significantly reduces LPA. For human ATX and rat ATX, the IC50s values are 2.2 nM and 3.4 nM , respectively.		Others
T72837	Autotaxin-IN-6
	Autotaxin-IN-6 (compound 23) is a potent inhibitor of autotaxin (ATX), exhibiting an IC50 of 30 nM, and is capable of attenuating cell migration with potential applications in anticancer research [1].
T27433	GRI918013	GRI 918013,GRI-918013
	GRI918013 is an ATX inhibitor.
T70275	PAT-347
	PAT-347 is a potent Autotaxin Inhibitor. Autotaxin (ATX) is a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline. The ATX-LPA signali...
T28300	PAT-347 sodium	PAT-347,PAT347,PAT 347
	PAT-347 is a potent inhibitor of Autotaxin (ATX), a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline.
T81804	MEY-003
	MEY-003, an Autotaxin (ATX) inhibitor, exhibits EC50 values of 460 nM for hATX-β and 1.09 μM for hATX-ɣ (analysis with LPC18:1), demonstrating its potency against these isoforms. It acts non-competitively with a K i of 4...
T69652	Relutrigine	PRAX-562
	Relutrigine (PRAX-562), an orally active persistent sodium channel inhibitor, potently and selectively targets persistent I Na, induced either by ATX-II (Nav 1.5 activator) or SCN8A mutation N1768D, with IC 50 values of ...
T14352	Autotaxin-IN-1		PDE
	Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treatment of osteoarthritis pain[1].		PDE
T38488	S32826
	S32826 is a highly potent inhibitor of autotaxin, exhibiting an IC50 value of 8.8 nM. It displays comparable inhibitory properties towards various autotaxin isoforms, including α, β, and γ. Furthermore, S32826 effectivel...
T23293	S32826 disodium	S 32826	Others
	autotaxin inhibitor		Others
T16434	PAT-048		PDE
	PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no effect on autotaxin protein and pulmonary lysophosphatidic ac...		PDE

Compounds

ATX inhibitor 5

T10409

Target: Sodium Channel

Target: Sodium Channel

Synonym: FK 614,ATx-08-001,ATx-08001,FK-614

Target:

CRT0273750

T31101

Synonym: CRT 0273750,CRT-0273750

Synonym: Autotaxin Inhibitor IV

Synonym: GRI 918013,GRI-918013

Synonym: PAT-347,PAT347,PAT 347

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02778	ENPP2 Protein, Human, Recombinant (His)	Human	HEK293
	ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen...
TMPH-00056	Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His)	Anemonia sulcata	Yeast
	Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent...
TMPY-02055	ENPP2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen...
TMPH-00409	BoNT/A Protein, Clostridium botulinum, Recombinant (His & SUMO)	Clostridium botulinum	E. coli
	BoNT/A Protein, Clostridium botulinum, Recombinant (His & SUMO) is expressed in E. coli.
TMPY-04122	ATOX1 Protein, Human, Recombinant (His)	Human	E. coli
	ATOX1 is a cytoplasmic copper chaperone that interacts with the copper-binding domain of the membrane copper transporters ATP7A and ATP7B. ATOX1 has also been suggested to have a potential anti-oxidant activity. As the t...
TMPY-00463	ENPP2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen...