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Autotaxin-IN-1

Catalog No. T14352 CAS 1619971-30-0

Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treatment of osteoarthritis pain[1].

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Autotaxin-IN-1, CAS 1619971-30-0

Pack Size	Availability	Price/USD
5 mg	8-10 weeks	$ 1,070.00
50 mg	8-10 weeks	$ 2,180.00
100 mg	8-10 weeks	$ 2,800.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treatment of osteoarthritis pain[1].
Targets&IC50	Autotaxin:2 nM
In vivo	Autotaxin-IN-1 (p.o.; 10 mg/kg) has Cmax of 660 nM and AUC of 3440 nM?h[1]. Autotaxin-IN-1 (i.v.; 1.0mg/kg) has T1/2 of 1.14 hours[1].

Molecular Weight	405.45
Formula	C21H23N7O2
CAS No.	1619971-30-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Jones SB, et al. Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design. ACS Med Chem Lett. 2016 Aug 2;7(9):857-61.

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Keywords

Autotaxin-IN-1 1619971-30-0 Metabolism PDE AutotaxinIN1 Autotaxin IN 1 Inhibitor inhibitor inhibit

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