Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HA130 is a selective ATX (autotaxin) inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 33.00 | |
5 mg | In stock | $ 52.00 | |
10 mg | In stock | $ 85.00 | |
25 mg | In stock | $ 148.00 | |
50 mg | In stock | $ 247.00 | |
100 mg | In stock | $ 370.00 | |
200 mg | In stock | $ 556.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 53.00 |
Description | HA130 is a selective ATX (autotaxin) inhibitor. |
Targets&IC50 | ATX:28 nM |
Kinase Assay | Saturation, association, and dissociation binding studies are performed for [3H]Vilanterol to determine receptor binding kinetics at the β2-AR (equilibrium dissociation constant (KD), total number of receptors (Bmax), association rate (kon), and dissociation rate (koff) are calculated). For saturation binding, membranes (in a volume of 1.4 mL to avoid ligand depletion) are incubated with increasing concentrations of [3H]Vilanterol (~0.01-1.3 nM) for 5 h before filtration. For association binding, membranes are incubated with different concentrations of [3H]Vilanterol (~0.1-1.9 nM) for varying incubation times up to 1 h before filtration. For dissociation binding, membranes are preincubated for 1 h with a fixed concentration of [3H]Vilanterol (~1.1 nM) before dissociation is initiated by a 1:20 dilution in binding buffer (containing 10 μM cold Vilanterol) and then incubated for varying times up to 8 h before filtration. Saturation binding is also completed for [3H]CGP12177 (increasing concentrations of ~0.01-2.8 nM) in the same format as described above for [3H]Vilanterol. To determine the affinity of β2-AR agonists and antagonists, competition binding displacement studies are completed in which membranes are incubated with a fixed concentration of [3H]Vilanterol (~0.2 nM) and increasing concentrations of unlabeled agonist/antagonist for 5 h before filtration. All competition binding displacement studies are completed in the presence of 100 μM Gpp(NH)p to ensure that binding curves are monophasic[1]. |
Molecular Weight | 463.29 |
Formula | C24H19BFNO5S |
CAS No. | 1229652-21-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 46.33 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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HA130 1229652-21-4 Metabolism PDE inhibit HA-130 HA 130 Phosphodiesterase (PDE) Inhibitor inhibitor