Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BI-2545 is an autotaxin (ATX) inhibitor that significantly reduces LPA. For human ATX and rat ATX, the IC50s values are 2.2 nM and 3.4 nM , respectively.
Description | BI-2545 is an autotaxin (ATX) inhibitor that significantly reduces LPA. For human ATX and rat ATX, the IC50s values are 2.2 nM and 3.4 nM , respectively. |
Targets&IC50 | ATX (human):3.4 nM, ATX (rat):, C50: 2.2 nM |
In vitro | BI-2545 displays good potency in the LPA and rat whole blood assay with IC50s of 29 nM and 96 nM, respectively[1]. |
In vivo | BI-2545 (10 mg/kg; p.o.) has high and sustained in vivo efficacy in reducing LPAs[1] and it also has a half-life of t1/2=3.4 hours[1]. |
Molecular Weight | 527.42 |
Formula | C23H19F6N5O3 |
CAS No. | 2162961-71-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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BI-2545 2162961-71-7 Others BI2545 BI 2545 inhibitor inhibit