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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T36968 | ARN-21934 | Topoisomerase | |
ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM as compared to the anticancer agent Etopo... | |||
T5993 | ARN-3236 | AMPK , SIK | |
ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM respectively). ARN-3236 Has anti-cancer activity. | |||
T5357 | ARN272 | ARN 272 | FAAH |
ARN272 is a FAAH-like anandamide transporter (FLAT) inhibitor (IC50: 1.8 μM). | |||
T2339 | Apalutamide | ARN-509 | Androgen Receptor , GABA Receptor |
Apalutamide (ARN-509) is a small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity. | |||
T25109 | ARN-6039 | ARN 6039,ARN6039 | |
ARN-6039 is an orally available inverse agonist of RORγ for Autoimmune Neuroinflammatory Demyelinating Disease. The activity of ARN-6039 against RORγ was demonstrated in a RORγ-activated IL-17A Prom/LUCPorter assay in HE... | |||
T71554 | ARN 14494 | ||
ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound preven... | |||
T5118 | Brilanestrant | GDC0810,GDC 0810,GDC-0810,ARN-810,RG 6046 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Brilanestrant (GDC-0810) is a selective estrogen receptor degrader (IC50: 0.7 nM). | |||
T10370 | ARN 077 | URB913 | Others |
ARN 077 is a selective N-acylethanolamine acid amidase (NAAA) inhibitor (IC50: 7 nM for human NAAA). ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS. | |||
T9528 | ARN19702 | Others | |
ARN19702 is a selective, orally active, reversible, and brain-penetrant N-acylethanolamine acid amidase (NAAA) inhibitor with an IC 50 of 230 nM for human NAAA. ARN19702 exhibits a broad analgesic profile [1] [2]. | |||
T7490 | ARN2966 | Beta Amyloid | |
ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion. | |||
T21658 | ARN14974 | Others | |
ARN14974 is a benzoxazolone carboxamide. ARN14974 is a potent inhibitor of acid ceramidase with IC50 of 79 nM[1]. | |||
T83950 | ARN 11391 | ||
ARN 11391 enhances the function of the IP3-gated calcium channel ITPR1 (Inositol 1,4,5-trisphosphate (IP3) receptor type 1), boosting intracellular calcium ion signaling by directly targeting ITPR1. Furthermore, ARN 1139... | |||
T71553 | Ainsliadimer A | ||
Ainsliadimer A, a sesquiterpene lactone dimer from Ainsliaea macrocephala, has antitumour activity and induces cell death in various cancer cells. | |||
T69606 | ARN23746 | ||
ARN23746 is a NKCC1 Inhibitor for the Treatment of Core Symptoms in Down Syndrome. | |||
T39859 | ARN19689 | ||
ARN19689 is an effective inhibitor of human NAAA, demonstrating high potency in the low nanomolar range (IC 50 = 0.042 μM). The compound acts through a non-covalent mechanism, highlighting its ability to interact with th... | |||
T30137 | ARN14686 | ||
ARN14686 is an activity-based affinity probe for the detection of N-acylethanolamine acid amidase (NAAA) using click chemistry. | |||
T14321 | ARN19874 | Others | |
ARN19874 is a selective, reversible uncompetitive N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) activity inhibitor. With an IC50 of ~34 μM[1]. | |||
T36969 | ARN24139 | ||
ARN24139 is a topoisomerase II poison (IC50= 7.3 μM in a topoisomerase II decatenation assay).1It inhibits proliferation of DU145, HeLa, and A549 cells (IC50s = 4.7, 3.8, and 3.1 μM, respectively). 1.Arencibia, J.M., Bri... | |||
T36468 | ARN14988 | ||
ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme). It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1,... | |||
T2318 | Sacubitril/Valsartan | Sacubitril mixture with Valsartan,Valsartan,Sacubitril,LCZ696 | Apoptosis , RAAS , Neprilysin |
Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure. |