ak4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4140	IRAK4-IN-1		IRAK
	IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.		IRAK
T62714	IRAK4-IN-20	BAY-1834845	IRAK
	IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM). IRAK4-IN-20, which has anti-inflammatory, antitumor and anticancer effects, is often used to treat acute respiratory distress syndrome (ARDS).		IRAK
T11673	IRAK4-IN-4		IRAK , cGAS
	IRAK4-IN-4 (compound 15) inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor, has an IC50 of 2.8 nM.		IRAK , cGAS
T5354	IRAK4-IN-7	CA-4948	IRAK
	IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.		IRAK
T63388	IRAK4-IN-8		IRAK
	IRAK4-IN-8 (VI-177) is an IRAK4 inhibitor for the study of diseases associated with cancer and inflammation.		IRAK
T63315	IRAK4-IN-19
	IRAK4-IN-19 is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK4) (IC50: 4.3 nM).IRAK4-IN-19 inhibits LPS-induced IL23 production in THP and DC cells and suppresses the development of arthritis in a...
T62989	IRAK4-IN-12
	IRAK4-IN-12 (compound 37) is a potent inhibitor of IRAK4 (IC50: 0.015 μM) with cellular pIRAK4 potency (IC50: 0.5 μM).
T63278	IRAK4-IN-14
	IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect.
T81569	PAK4-IN-3		PAK
	PAK4-IN-3 (compound 27e) is a PAK4 inhibitor exhibiting an IC50 of 10 nM and demonstrates antiproliferative effects on A549 cells with an IC50 of 0.61μM. It also induces concentration-dependent apoptosis in A549 cells an...		PAK
T39902	PROTAC IRAK4 degrader-5	PROTAC IRAK4 degrader-5
	PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader.
T63559	IRAK4-IN-22
	IRAK4-IN-22 is a selective, orally active, potent IRAK4 inhibitor that acts on IRAK4 (IC50: 3 nM) and TAK1 (IC50: 17 nM). IRAK4-IN-21 exhibits potent inhibition of IL-23 production with an IC50 value of 0.10 μM. IRAK4-IN...
T39920	PROTAC IRAK4 degrader-3	PROTAC IRAK4 degrader-3
	PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau.
T39903	PROTAC IRAK4 degrader-6	PROTAC IRAK4 degrader-6
	PROTAC IRAK4 degrader-6 is a potent Cereblon-based compound designed to degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
T74062	PROTAC IRAK4 degrader-2
	PROTAC IRAK4 Degrader-2 (Compound 9) is a PROTAC-based degrader that potently reduces IRAK4 levels, achieving a DC50 of 151 nM in peripheral blood mononuclear cells (PBMCs). It also notably decreases IRAK4 protein levels...
T78744	IRAK4-IN-24		IRAK
	IRAK4-IN-24 (compound 16), a potent IRAK4 inhibitor, exhibits high clearance (Cl) and low oral bioavailability. It is utilized in research pertaining to inflammatory and autoimmune disorders.		IRAK
T63262	IRAK4-IN-15
	IRAK4-IN-15 is a selective and potent IRAK4 inhibitor (IC50: 0.002 μM) with good human PK prediction and low intrinsic clearance.IRAK4-IN-15 in combination with Acalabrutinib exhibited potent synergistic in vitro activit...
T79097	PROTAC IRAK4 degrader-8		IRAK
	PROTAC IRAK4 Degrader-8 (Compound 2) is a PROTAC designed to target IRAK4 with an IC50 of 15.5 nM [1].		IRAK
T79447	IRAK4-IN-25		IRAK
	IRAK4-IN-25 (compound 38), a potent oral IRAK4 inhibitor (IC50 = 7.3 nM) with low clearance (Cl = 12 mL/min/kg), effectively suppresses pro-inflammatory cytokine production and demonstrates favorable in vitro safety and ...		IRAK
T11674	IRAK4-IN-6		Others
	IRAK4-IN-6 is a selective and orally efficacious inhibitor of IRAK4, demonstrating an IC50 value of 4 nM. This compound specifically targets MyD88 L265P mutant diffuse large B-cell lymphoma [1].		Others
T61931	IRAK4-IN-10
	IRAK4-IN-10 (compound 75) is an effective IRAK4 inhibitor (IC50 is 1.5 nM), which can block the MyD88-dependent signal pathway. IRAK4-IN-10 has research potential in inflammatory diseases, autoimmune diseases and cancer.
T60899	IRAK4-IN-11
	IRAK4-IN-11 (compound 6) is a potent inhibitor of IRAK4 with an IC 50 of 0.008 μM. IRAK4-IN-11 exhibits cell pIRAK4 potencies with an IC 50 of 0.19 μM [1].
T79337	IRAK4-IN-28		IRAK
	IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a Kd of 0.58 nM for the target enzyme. It is utilized for research purposes in the study of inflammation an...		IRAK
T63558	IRAK4-IN-21
	IRAK4-IN-21 is a selective, orally active, potent IRAK4 inhibitor that acts on IRAK4 (IC50: 5 nM) and TAK1 (IC50: 56 nM). IRAK4-IN-21 exhibits potent inhibition of IL-23 production with an IC50 value of 0.17 μM. can be ...
T79448	IRAK4-IN-26		IRAK
	IRAK4-IN-26 (Compound 21), an IRAK4 inhibitor with an IC50 of 6.2 nM, exhibits an oral bioavailability of 21%. It is utilized for the study of inflammatory and autoimmune disorders [1].		IRAK
T61734	IRAK4-IN-9
	IRAK4-IN-9 (compound 73) is a highly potent inhibitor of IRAK4, displaying an impressive IC50 value of 1.5 nM. By blocking MyD88-dependent signaling, IRAK4-IN-9 exhibits promising potential for the investigation of infla...
T62850	IRAK4-IN-13
	IRAK4-IN-13 (compound 21) is a selective and potent IRAK4 inhibitor (IC50: 0.6 nM). iRAK4-IN-13 has a high metabolic clearance, with an intrinsic human liver microsomal (HLM) clearance of 96 μL/min/mg.
T13843	PROTAC IRAK4 ligand-1		Others
	PROTAC IRAK4 ligand-1 is a synthetic ligand for interleukin-1 receptor-associated kinase 4.		Others
T62950	IRAK4-IN-18
	IRAK4-IN-18 is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK4) (IC50: 15 nM). IRAK4-IN-18 inhibits LPS-induced IL23 production in THP and DC cells and blocks the development of arthritis in rats,...
T13842	PROTAC IRAK4 degrader-1		Others
	PROTAC IRAK4 degrader-1 is a degrader of PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4).		Others
T24174	IRAK4-IN-16
	IRAK4-IN-16 (compound 4) is a potent inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with an IC 50 of 2.5 nM. IRAK4-IN-16 exhibits cytotoxicity activity against OCI-LY10, TMD8, Ramos and HT cells, with IC...
T61767	IRAK4-IN-17
	IRAK4-IN-17 (Compound 5) is a highly potent inhibitor of IRAK4, exhibiting an impressive IC50 value of 1.3 nM [1]. This compound is particularly valuable for research focused on large B-cell lymphoma (DLBCL) [1].
T39901	PROTAC IRAK4 degrader-4	PROTAC IRAK4 degrader-4
	PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
T79485	IRAK4-IN-27		IRAK
	IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM. It effectively suppresses cell growth and induces apoptosis in the MYD88 L265P diffuse large B-cell lymphoma (DLBCL) c...		IRAK
T81378	PROTAC IRAK4 ligand-3		PROTACs
	PROTAC IRAK4 Ligand-3 serves as a ligand for PROTAC IRAK4 Degrader-7 and is utilized in cancer research [1].		PROTACs
T74411	PROTAC IRAK4 degrader-7
	PROTAC IRAK4 degrader-7 (Compound I-417) is an orally administered agent with antitumor properties, functioning as a PROTAC IRAK4 degrader [1].
T61299	PAK4-IN-2
	PAK4-IN-2 is an exceptionally effective inhibitor of PAK4, exhibiting an IC 50 value of 2.7 nM. This compound is capable of arresting MV4-11 cells at the G0/G1 phase and inducing cell apoptosis. It holds significant pote...
T63934	PAK4-IN-1
	PAK4-IN-1 is a selective, potent, orally active PAK4 inhibitor that is stable under both acidic and neutral conditions.PAK4-IN-1 exhibits good anti-tumour effects in vivo.

Compounds

IRAK4-IN-1

T4140

PROTAC IRAK4 degrader-5

T39902

Synonym: PROTAC IRAK4 degrader-5

PROTAC IRAK4 degrader-3

T39920

Synonym: PROTAC IRAK4 degrader-3

Target:

PROTAC IRAK4 degrader-6

T39903

Synonym: PROTAC IRAK4 degrader-6

Target:

PROTAC IRAK4 degrader-2

PROTAC IRAK4 degrader-8

PROTAC IRAK4 ligand-1

PROTAC IRAK4 degrader-1

PROTAC IRAK4 degrader-4

T39901

Synonym: PROTAC IRAK4 degrader-4

PROTAC IRAK4 ligand-3

T81378

Synonym:

Target: PROTACs

PROTAC IRAK4 degrader-7

Cat No.	Product Name	Species	Expression System
TMPY-04469	AK3L1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	AK3L1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 53 kDa and the accession number is P27144-1.
TMPY-04755	AK3L1 Protein, Human, Recombinant	Human	Baculovirus Insect Cells
	AK3L1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 25.3 kDa and the accession number is P27144-1.
TMPY-04483	IRAK4 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4...

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Recombinant Proteins