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Selfotel

Name: Selfotel
Brand: TargetMol
SKU: T22654
Rating: 4.5 (1 reviews)

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Catalog No. T22654Cas No. 110347-85-8

Alias LY-272541, CGS 19755

Selfotel is a NMDA receptor antagonist.

Selfotel

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Purity: 99.67%

Catalog No. T22654Alias LY-272541, CGS 19755Cas No. 110347-85-8

Selfotel is a NMDA receptor antagonist.

Product information is being updated, if you want to purchase, please click the bulk custom button.

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Batch Information

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Purity:99.67%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Selfotel is a NMDA receptor antagonist.
Targets&IC50	NMDA:50 nM
In vitro	CGS 19755 reduces neuronal death concentration-dependently as assessed by phase-contrast microscopy and by measurement of LDH release into the bathing medium 20-24 h later with the mean (±SD) ED50 for CGS 19755 against NMDA toxicity of 25.4 ± 30.8 μM, determined from 6 experiments, each using 4 cultures per condition[1].
In vivo	Selfotel blocks the harmaline-induced increase in cerebellar cyclic GMP levels (4 mg/kg i.p. 2 hr) and inhibits convulsions elicited by maximal electroshock in rats with ED50 of 3.8 mg/kg at 1 hr after i.p. administration and in mice with ED50 of 2.0 mg/kg at 0.5 hr after i.p. administration)[1]. P.O. administration of Selfotel by gavage has little or no effect in an experimental model of anxiety in rats while Selfotel significantly increases conflict responding within a relatively narrow dose range at the minimum effective dose of 1.73 mg/kg i.p.[2].
Synonyms	LY-272541, CGS 19755

Chemical Properties

Molecular Weight	223.16
Formula	C₇H₁₄NO₅P
Cas No.	110347-85-8
Smiles	OC(=O)[C@H]1C[C@@H](CP(O)(O)=O)CCN1
Relative Density.	1.440 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble)

H2O: 13.1 mg/mL (58.7 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	4.4811 mL	22.4054 mL	44.8109 mL	224.0545 mL
5 mM	0.8962 mL	4.4811 mL	8.9622 mL	44.8109 mL
10 mM	0.4481 mL	2.2405 mL	4.4811 mL	22.4054 mL
20 mM	0.2241 mL	1.1203 mL	2.2405 mL	11.2027 mL
50 mM	0.0896 mL	0.4481 mL	0.8962 mL	4.4811 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc