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VGX-1027

Catalog No. T1813 CAS 6501-72-0

Synonyms: VGX1027, VGX 1027, GIT 27

VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

VGX-1027, CAS 6501-72-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 42.00
10 mg	In stock	$ 68.00
25 mg	In stock	$ 142.00
50 mg	In stock	$ 229.00
100 mg	In stock	$ 367.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.86%

Purity: 99.54%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties.
In vitro	VGX-1027 enhances survival rates and ameliorates clinical and histopathological signs in the NZB/NZW F1 model of systemic lupus erythematosus, thereby improving disease progression. It prevents the spontaneous development of Type 1 diabetes in NOD mice and counters the acceleration of diabetes induced either by cyclophosphamide assault or by the adoptive transfer of diabetogenic spleen cells in NOD mice. Furthermore, VGX-1027 reduces clinical symptoms of diabetes induced by MLD-STZ and inhibits pathological histological changes in the pancreas.
In vivo	VGX-1027 exhibits inhibitory effects on the proliferation of gut bacterial antigen-reactive CD4+ CD25- T cells in vitro. It significantly suppresses the accumulation of TNF-α and nitrites induced by IL-1β/IFN-γ, and notably enhances cell survival by interfering with the toxic effects of cytokines.

Synonyms	VGX1027, VGX 1027, GIT 27
Molecular Weight	205.21
Formula	C11H11NO3
CAS No.	6501-72-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20.5 mg/mL (100 mM)

References and Literature

1. Stosic-Grujicic S, et al. J Pharmacol Exp Ther. 2007, 320(3), 1038-1049. 2. Mangano K, et al. Eur J Pharmacol. 2008, 586(1-3), 313-321.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Aging Compound Library Apoptosis Compound Library Angiogenesis related Compound Library Anti-Fibrosis Compound Library Nonsteroidal Anti-Inflammatory Compound Library Orally Active Compound Library NF-κB Signaling Compound Library Autophagy Compound Library HIF-1 Signaling Pathway Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

VGX-1027 6501-72-0 Apoptosis Immunology/Inflammation IL Receptor TNF Interleukin Tumor Necrosis Factor Receptor VGX1027 inhibit Interleukin Related GIT27 Inhibitor TNF Receptor VGX 1027 TNFR GIT 27 GIT-27 inhibitor

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