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Trigonelline

Catalog No. T2887   CAS 535-83-1
Synonyms: Trigenolline

Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.

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Trigonelline Chemical Structure
Trigonelline, CAS 535-83-1
Pack Size Availability Price/USD Quantity
5 mg In stock $ 33.00
10 mg In stock $ 55.00
25 mg In stock $ 90.00
50 mg In stock $ 128.00
100 mg In stock $ 172.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.
In vitro Treatment of cells with Trigonelline attenuates H2O2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9, and anti-apoptotic gene Bcl-2, Bcl-XL during H2O2 induced oxidative stress in H9c2 cells. Trigonelline significantly reduces the H2O2 induced necrosis and apoptosis in H9c2 cells. However, the further increment of Trigonelline concentration against H2O2 can induce the necrosis and apoptosis along with H2O2[1].
In vivo Trigonelline decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. Trigonelline significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength in nicotinamide/streptozotocin-treated rats. Trigonelline differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders like intensify the osteoporotic changes in streptozotocin-treated rats and favorably affect bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats[2].
Source
Synonyms Trigenolline
Molecular Weight 137.14
Formula C7H7NO2
CAS No. 535-83-1

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 10 mM

Ethanol: Insoluble

TargetMolReferences and Literature

1. Ilavenil S, et al. Trigonelline protects the cardiocyte from hydrogen peroxide induced apoptosis in H9c2 cells. Asian Pac J Trop Med. 2015 Apr;8(4):263-8. 2. Joanna Folwarczna, et al. Effects of Trigonelline, an Alkaloid Present in Coffee, on Diabetes-Induced Disorders in the Rat Skeletal System. Nutrients. 2016 Mar; 8(3): 133.

Related compound libraries

This product is contained In the following compound libraries:
Tobacco Monomer Library Anti-Cancer Active Compound Library Marine Natural Product Library Traditional Mongolian Medicine Compound Library FDA-Approved & Pharmacopeia Drug Library Traditional Chinese Medicine Monomer Library Anti-Cancer Compound Library Bioactive Compounds Library Max Apoptosis Compound Library Ferroptosis Compound Library

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Keywords

Trigonelline 535-83-1 Apoptosis Metabolism Others Ferroptosis Endogenous Metabolite Inhibitor Trigenolline inhibit inhibitor

 

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