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Soticlestat

Catalog No. T8937 CAS 1429505-03-2

Synonyms: TAK-935, OV935

Soticlestat (OV935) is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Soticlestat, CAS 1429505-03-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 60.00
5 mg	In stock	$ 147.00
10 mg	In stock	$ 239.00
25 mg	In stock	$ 478.00
50 mg	In stock	$ 688.00
100 mg	In stock	$ 996.00
1 mL * 10 mM (in DMSO)	In stock	$ 162.00

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Purity: 99.95%

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Storage & Solubility Information

Description	Soticlestat (OV935) is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research.
In vitro	Soticlestat inhibits the catalytic activity of human cholesterol 24-hydroxylase (CH24H) in a concentration-dependent manner with an IC50?of 4.5 nM
In vivo	Soticlestat treatment lowers brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduceds premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%. Soticlestat can suppress potassium-evoked extracellular glutamate elevations in the hippocampus

Synonyms	TAK-935, OV935
Molecular Weight	373.45
Formula	C23H23N3O2
CAS No.	1429505-03-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (267.77 mM), Sonication is recommended.

References and Literature

1. Toshiya Nishi, et al. Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice. Sci Rep. 2020 Oct 13;10(1):17081. 2. Krista Eschbach, et al. Stiripentol for the treatment of seizures in Dravet syndrome. Expert Rev Clin Pharmacol. 2019 May;12(5):379-388.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Inhibitor Library Clinical Compound Library Metabolism Compound Library Orally Active Compound Library Pediatric Drug Library Bioactive Compound Library Anti-Aging Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Soticlestat 1429505-03-2 Metabolism P450 Inhibitor CYP46A1 inhibit TAK935 cholesterol 24-hydroxylase NMDA antiepileptic TAK-935 OV935 OV 935 CYPs epilepsy TAK 935 OV-935 Cytochrome P450 inhibitor

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