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SB 242235

Catalog No. T4078 CAS 193746-75-7

Synonyms: SB-242235, SB242235

SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.

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SB 242235, CAS 193746-75-7

Pack Size	Availability	Price/USD
2 mg	In stock	$ 40.00
5 mg	In stock	$ 67.00
10 mg	In stock	$ 118.00
25 mg	In stock	$ 249.00
50 mg	In stock	$ 378.00
100 mg	In stock	$ 568.00
1 mL * 10 mM (in DMSO)	In stock	$ 75.00

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Purity: 99.68%

Purity: 99.14%

Purity: 99.13%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.
Targets&IC50	p38 MAP kinase:1.0 μM

Synonyms	SB-242235, SB242235
Molecular Weight	353.39
Formula	C19H20FN5O
CAS No.	193746-75-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 48 mg/mL

References and Literature

1. Badger, A.M., et al., Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures. Osteoarthritis Cartilage, 2000. 8(6): p. 434-43. 2. Ward, K.W., et al., SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. I: preclinical pharmacokinetics. Xenobiotica, 2002. 32(3): p. 221-33. 3. Kim, A.L., et al., Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice. J Invest Dermatol, 2005. 124(6): p. 1318-25. 4. Ward, K.W., et al., SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. II: in vitro and in vivo metabolism studies and pharmacokinetic extrapolation to man. Xenobiotica, 2002. 32(3): p. 235-50.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Kinase Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Inhibitor Library Anti-Pancreatic Cancer Compound Library MAPK Inhibitor Library Anti-Obesity Compound Library Cytoskeletal Signaling Pathway Compound Library Anti-Liver Cancer Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SB 242235 193746-75-7 Autophagy MAPK p38 MAPK SB-242235 inhibit SB242235 Inhibitor inhibitor

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