Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lucidenic acid D2 is a nartural product from G. lucidum AF.
Pack Size | Availability | Price/USD | Quantity |
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5 mg | Inquiry | $ 954.00 |
Description | Lucidenic acid D2 is a nartural product from G. lucidum AF. |
In vitro | Here, we showed that triterpenes-rich extract of antlered form of G. lucidum (G. lucidum AF) induces TNFα± production in monocytic THP-1 cells. Furthermore, the extract also synergized with lipopolysaccharide (LPS) to induce TNFα± production in THP-1 cells, suggesting an immunostimulatory role of triterpenes-rich extract of G. lucidum AF. Notably, the extract enhanced LPS-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK), while it suppressed LPS-induced phosphorylation of c-Jun N-terminal kinase (JNK) MAPK. p38 Inhibitor suppressed TNFα± production, while JNK inhibitor enhanced TNFα± production, implying that synergistic effect of the extract may work by modulating p38 and JNK MAPKs. Moreover, we found that the triterpenes-rich extract of G. lucidum AF contains high amounts of lucidenic acids. Lucidenic acid A, Lucidenic acid F and Lucidenic acid D2, which seem to dominantly exist in the extract, were purified from the triterpenes-rich extract. We also identified Lucidenic acid-A and -F as modulators of JNK and p38, respectively. |
Synonyms | Lucidenic acid D2 |
Molecular Weight | 514.61 |
Formula | C29H38O8 |
CAS No. | 98665-16-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Lucidenic acid D 98665-16-8 Apoptosis MAPK TNF p38 MAPK Lucidenic acid D2 inhibitor inhibit