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Reserpine

Catalog No. T0791 CAS 50-55-5

Synonyms: Serpivite, Serpalan, 利血平, Serpasil

Reserpine is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.

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Reserpine, CAS 50-55-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Serpivite, Serpalan, 利血平, Serpasil
Molecular Weight	608.68
Formula	C33H40N2O9
CAS No.	50-55-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 6.1 mg/mL (10 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Schmitz FJ, et al. J Antimicrob Chemother, 1998, 42(6), 807-810. 2. Kannari K, et al. J Neurochem, 2000, 74(1), 263-269. 3. Ceccatelli S, et al. Brain Res Mol Brain Res, 1991, 9(1-2), 57-69. 4. Cai JX, et al. Brain Res, 1993, 614(1-2), 191-196. 5. Burger ME, et al. Brain Res, 2005, 1031(2), 202-210. 6. Antkiewicz-Michaluk L, et al. Withdrawal from repeated administration of a low dose of reserpine induced opposing adaptive changes in the noradrenaline and serotonin system function: a behavioral and neurochemical ex vivo and in vivo studies in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Mar 3;57:146-54. 7. Hong B, et al. Reserpine Inhibit the JB6 P+ Cell Transformation Through Epigenetic Reactivation of Nrf2-Mediated Anti-oxidative Stress Pathway. AAPS J. 2016 May;18(3):659-69.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Autophagy Compound Library Anti-Cardiovascular Disease Compound Library Traditional Chinese Medicine Monomer Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Natural Product Library for HTS Ion Channel Inhibitor Library Anti-Tumor Natural Product Library Immunology/Inflammation Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Reserpine 50-55-5 离子通道免疫与炎症其他自噬 Autophagy Monoamine Transporter MRP Others Potassium Channel Serpivite Serpalan Inhibitor Serpasil inhibit inhibitor

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