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Reserpine

Reserpine
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Purity:99.6%
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Reserpine

Catalog No. T0791Cas No. 50-55-5
Reserpine (Serpalan) is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
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Pack SizePriceAvailabilityQuantity
50 mg$36In Stock
100 mg$52In Stock
500 mg$125In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
Reserpine (Serpalan) is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
In vitro
Compared to the control group, alternate-day subcutaneous injections of reserpine solution (1 mg/kg s.c.) for three days significantly increased the duration of vacuous chewing, tongue protrusion, and facial twitching in rats. Reserpine reduced glutamate uptake in the cortical region of rats and caused a significant depletion of vasopressin/oxytocin - neurophysin-like immunoreactivity (LI) and CRH-L1 in the rat's median eminence. Additionally, reserpine notably restored performance in the delayed response task in monkeys. At a dose of 5 mg/kg, reserpine significantly increased pointless jaw movements in monkeys and reduced grooming behavior across all age groups in rats. A subcutaneous injection of 5 mg/kg reserpine in intact rats decreased extracellular dopamine levels to 4% of baseline values. The impact of reserpine on performance in a visual discrimination task, a reference memory task not reliant on the prefrontal cortex, was minimal.
In vivo
Reserpine was demonstrated to inhibit efflux pumps in 11, 21, and 48 out of the 102 unrelated clinical isolates tested, resulting in a fourfold decrease in the IC50 values and MICs of sparfloxacin, moxifloxacin, and ciprofloxacin, respectively.
AliasSerpalan, Serpasil, Serpivite
Chemical Properties
Molecular Weight608.68
FormulaC33H40N2O9
Cas No.50-55-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 6.1 mg/mL (10 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6429 mL8.2145 mL16.4290 mL82.1450 mL
5 mM0.3286 mL1.6429 mL3.2858 mL16.4290 mL

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