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RWJ-67657

Catalog No. T16812 CAS 215303-72-3

Synonyms: JNJ 3026582

RWJ-67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor (IC50s: 1 and 11 μM, respectively). RWJ-67657 shows no activity at p38γ and p38δ and shows a cardioprotective effect.

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RWJ-67657, CAS 215303-72-3

Pack Size	Availability	Price/USD
2 mg	In stock	$ 39.00
5 mg	In stock	$ 64.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 228.00
50 mg	In stock	$ 368.00
100 mg	In stock	$ 593.00
500 mg	In stock	$ 1,250.00
1 mL * 10 mM (in DMSO)	In stock	$ 70.00

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Purity: 98.28%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	RWJ-67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor (IC50s: 1 and 11 μM, respectively). RWJ-67657 shows no activity at p38γ and p38δ and shows a cardioprotective effect.
Targets&IC50	p38β:11 μM, p38α:1 μM
In vitro	RWJ-67657 suppresses the release of TNF-α by lipopolysaccharide (LPS)-treated human peripheral blood mononuclear cells (IC50: 3 nM) and the release of TNF-α from peripheral blood mononuclear cells treated with the superantigen staphylococcal enterotoxin B (IC50: 13 nM). RWJ67657 (10 μM; 24 hours) reduces colony formation in MCF-7 cells [2][3].
In vivo	RWJ-67657 inhibits TNF-alpha production in lipopolysaccharide-injected mice (87% inhibition at 50 mg/kg) and in rats (91% inhibition at 25 mg/kg) after oral administration. RWJ-67657 (50 mg/kg; p.o.; once per day for 7 consecutive days) shows an effective anti-inflammatory effect. EPC transplantation plus RWJ-67657 administration synergistically promotes angiogenesis and neurogenesis after diabetic stroke by both improving the functioning of endothelial progenitor cells and reducing inflammation [2][4].

Synonyms	JNJ 3026582
Molecular Weight	425.5
Formula	C27H24FN3O
CAS No.	215303-72-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (293.77 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Shahin R, et al. Research advances in kinase enzymes and inhibitors for cardiovascular disease treatment. Future Sci OA. 2017 Aug 8;3(4):FSO204. 2. Wadsworth SA, et al. RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase. J Pharmacol Exp Ther. 1999 Nov;291(2):680-7. 3. Frigo DE, et al. p38 mitogen-activated protein kinase stimulates estrogen-mediated transcription and proliferation through the phosphorylation and potentiation of the p160 coactivator glucocorticoid receptor-interacting protein 1. Mol Endocrinol. 2006 May;20(5):971-83. 4. Bai YY, et al. Synergistic Effects of Transplanted Endothelial Progenitor Cells and RWJ 67657 in Diabetic Ischemic Stroke Models. Stroke. 2015 Jul;46(7):1938-46.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Kinase Inhibitor Library Inhibitor Library Osteogenesis Compound Library MAPK Inhibitor Library NO PAINS Compound Library Bioactive Compounds Library Max Pyroptosis Compound Library Bioactive Compound Library Immunology/Inflammation Compound Library

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Keywords

RWJ-67657 215303-72-3 MAPK p38 MAPK RWJ67657 RWJ 67657 Inhibitor JNJ3026582 JNJ 3026582 anti-tumor JNJ-3026582 p38α protective. Anti-inflammatory MCF-7 inhibit inflammation cardio p38β inhibitor

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