Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RA375, an inhibitor of RPN13 (26S proteasome regulatory subunit), enhances UPR signaling, ROS production, and apoptosis. Demonstrating ten times the efficacy against cancer lines compared to RA190, RA375 owes its increased activity to nitro ring substituents and the inclusion of a chloroacetamide warhead.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 59.00 | |
5 mg | In stock | $ 148.00 | |
10 mg | In stock | $ 247.00 | |
25 mg | In stock | $ 418.00 | |
50 mg | In stock | $ 596.00 | |
100 mg | In stock | $ 863.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 198.00 |
Description | RA375, an inhibitor of RPN13 (26S proteasome regulatory subunit), enhances UPR signaling, ROS production, and apoptosis. Demonstrating ten times the efficacy against cancer lines compared to RA190, RA375 owes its increased activity to nitro ring substituents and the inclusion of a chloroacetamide warhead. |
In vivo | RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice[1]. |
Synonyms | RA375 |
Molecular Weight | 588.99 |
Formula | C30H25ClN4O7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (212.22 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
RA375 Proteases/Proteasome Ubiquitination Proteasome RA-375 RA 375 inhibitor inhibit