proteasome — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T21854	Proteasome inhibitor IX	PS-IX,AM114	Proteasome
	Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). Proteasome inhibitor IX shows potent anticancer activity. Proteasome inhibitor IX exhibits HCT116 p53+/+ c...		Proteasome
T63321	20S Proteasome activator 1		Proteasome
	20S Proteasome activator 1 is a 20S proteasome activator with IC50 of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites and 1.8 μM for caspase sites. 20S Proteasome activator 1 prevents the accumulation o...		Proteasome
T12561	Proteasome-IN-1		Proteasome
	Proteasome-IN-1 is an inhibitor of proteasome.		Proteasome
T81371	Proteasome-IN-5		Proteasome
	Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].		Proteasome
T72762	Proteasome-IN-4
	Proteasome-IN-4, a non-covalent proteasome inhibitor (IC 50 = 8.39 nM), exhibits potent antiproliferative effects on RPMI-8226, MM-1S, and MV-4-11 cell lines, making it valuable for cancer research.
T71092	Proteasome-IN-3
	Proteasome-IN-3 is an inhibitor of proteasome-associated DUBs.
T81372	Proteasome-activating peptide 1
	Proteasome-activating peptide 1 enhances chymotrypsin-like proteasomal catalytic activity, boosting proteolytic rates both in vitro and within cultured cells. Additionally, it inhibits protein aggregation in a cellular m...
T62255	20S Proteasome-IN-4
	20S Proteasome-IN-4 (Compound 7) is an orally active inhibitor of the 20S proteasome, selectively targeting the parasite form and demonstrating brain penetration capabilities. It exhibits a potent IC50 value of 6.3 nM ag...
T76243	Proteasome-activating peptide 1 TFA
	Proteasome-activating peptide 1 TFA is a potent activator of the proteasome, enhancing chymotrypsin-like proteasomal catalytic activity and thereby increasing proteolytic rates both in vitro and in culture. Additionally,...
T81373	Proteasome β2c/i-IN-1		Proteasome
	Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].		Proteasome
T9710	Dazcapistat		Cysteine Protease
	Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.		Cysteine Protease
T78625	Z-Ala-Arg-Arg-AMC	Z-ARR-AMC,Fluorogenic Proteasome Substrate	Proteasome
	Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) serves as a fluorogenic substrate designed to assay the trypsin-like activity within the proteasome [1].		Proteasome
T6432	Calpeptin		Apoptosis , Cysteine Protease , Proteasome
	Calpeptin is a potent, cell-permeable calpain inhibitor.		Apoptosis , Cysteine Protease , Proteasome
T9090	MUN57694		Proteasome
	MUN57694 is an inhibitor of 26S proteasome.		Proteasome
T7016	VR23		Apoptosis , Proteasome , Caspase
	VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM for caspase-like proteasomes.		Apoptosis , Proteasome , Caspase
T13858	RA190		Proteasome
	RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.		Proteasome
T3786	Tomatine	lycopersicin	Apoptosis , Proteasome
	Tomatine (lycopersicin) is an antiproliferatve agent of breast adenocarcinoma cells.		Apoptosis , Proteasome
T7814	Alloxan monohydrate		Proteasome
	Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.		Proteasome
T2122	Ixazomib	MLN2238	Proteasome , Caspase , Autophagy
	Ixazomib (MLN2238) , a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC50/Ki: 3.4/0.93 nM, in cell-free assays), also i...		Proteasome , Caspase , Autophagy
T6941	PI-1840	PI 1840	PARP , Proteasome
	PI-1840（IC50 = 27 nM）is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L).		PARP , Proteasome