Ubiquitination Compound Library

Catalog No. L8600

Library Compound List Excel SDF

Ubiquitination involves covalent attachment of ubiquitin, a small 8-kDa protein, to a substrate and results in recognition and shuttling of the substrate to the 26S proteasome complex for degradation. Ubiquitination, the structured degradation and turnover of cellular proteins, is regulated by the ubiquitin–proteasome system (UPS). The ubiquitination process is tightly controlled by three families of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and finally ubiquitin ligases (E3s). Ubiquitination affects cellular process (apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc.) by regulating the degradation of proteins (via the proteasome and lysosome), coordinating the cellular localization of proteins, activating and inactivating proteins, and modulating protein-protein interactions. The ubiquitin pathway has been implicated in the pathogenesis of several diseases and genetic disorders: cancer, cardiovascular disease, and neurodegenerative disorders, etc. Recent advances in our understanding of the role and molecular mechanisms of UPS components in disease – mainly DUBs and E3 ligases, the development of high-quality chemical tools and novel inhibitors, as well as preclinical studies demonstrating chemical tractability and therapeutic potential – have dramatically taken the ubiquitin proteasome system from an improbable target class, to one of the most robust and exciting arenas for the discovery of novel drugs.

TargetMol’s Ubiquitination Compound Library collects 214 ubiquitination related small molecules, targeting proteasome, E1/E2/E3 Enzyme, DUB, p97, etc.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

Request for Quote

If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

Request Library

Product Description

A unique collection of 214 ubiquitination related small chemicals can be used for high throughput and high content screening；
Targets include proteasome, E1/E2/E3 Enzyme, DUB, p97, etc.;
Detailed compound information with structure, target, and biological activity description；
NMR and HPLC validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cells. 2022, 11(18): 2839. 2. Molecules. 2024, 29(2): 482. 3. Animal Cells and Systems. 2023, 27(1): 394-402. 4. Cell Stem Cell. 2022 Apr 29(4) 545–558. 5. Science Bulletin. 2022. 6. Science Translational Medicine. 2022, 14(656): eabn3231. 7. Science Advances. 2023, 9(9): eade3760. 8. Nature. 2020, 582: 289-293. 9. Nature Biotechnology. 2021, 39(11): 1444-1452.

10. Nature Communications. 2022, 13(1): 1-15.. 11. Nature Communications. 2023, 14(1): 1020.. 12. Nature Communications. 2023, 14(1): 2756.. 13. Blood. 2021, 137(11): 1478-1490. 14. Nucleic Acids Research. 2021. 15. Nature Communications. 2023, 14(1): 7574. 16. Advanced Science. 2020, 7(16): 2000925. 17. Angewandte Chemie. 2021. 18. Acta Pharmaceutica Sinica B. 2022. 19. Protein & Cell. 2021, 12(11): 877-888. 20. Bone Research. 2023, 11(1): 54. 21. Pharmacology & Therapeutics. (2021): 107930. 22. Nature Communications. 2021, 12(1): 1-12. 23. Journal of Cell Biology. 2022, 221(5): e202112024. 24. Kim S H, Bae J E, Park N Y, et al.Evaluation of Teneligliptin and Retagliptin on the Clearance of Melanosome by Melanophagy in B16F1 Cells.Cosmetics.2024, 11(2): 35.

See More... Hide

Library Composition

Proteasome (62)

E1/E2/E3 Enzyme (49)

Apoptosis (44)

DUB (41)

p53 (30)

Autophagy (29)

DPP-4 (20)

Mdm2 (18)

NF-κB (13)

Ferroptosis (8)

p97 (7)

Sirtuin (5)

Antibacterial (5)

Cysteine Protease (5)

HIV Protease (4)

Dehydrogenase (4)

Epigenetic Reader Domain (3)

IκB/IKK (3)

NEDD8 (3)

IAP (3)

BCL (3)

Caspase (3)

PARP (3)

Mitophagy (3)

Ligand for E3 Ligase (2)

MMP (2)

HDAC (2)

COX (2)

Endogenous Metabolite (2)

SARS-CoV (2)

PROTACs (2)

Bcr-Abl (2)

PPAR (2)

Aryl Hydrocarbon Receptor (2)

Antibiotic (2)

Antifungal (2)

DNA Alkylator/Crosslinker (2)

AMPK (1)

Neprilysin (1)

Retinoid Receptor (1)

HIF/HIF Prolyl-Hydroxylase (1)

Protease-activated Receptor (1)

TNF (1)

TAM Receptor (1)

BMI-1 (1)

DNA Methyltransferase (1)

Syk (1)

Potassium Channel (1)

Src (1)

HSV (1)

Aminopeptidase (1)

RIP kinase (1)

Amino Acids and Derivatives (1)

p38 MAPK (1)

Factor Xa (1)

Serine Protease (1)

PKC (1)

ERK (1)

HCV Protease (1)

PDE (1)

TLR (1)

CDK (1)

NMDAR (1)

Mitochondrial Metabolism (1)

Molecular Glues (1)

JAK (1)

IGF-1R (1)

HSP (1)

Reactive Oxygen Species (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty