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TargetMol | Compound Library

Ubiquitination Compound Library

Catalog No. L8600

Ubiquitination involves covalent attachment of ubiquitin, a small 8-kDa protein, to a substrate and results in recognition and shuttling of the substrate to the 26S proteasome complex for degradation. Ubiquitination, the structured degradation and turnover of cellular proteins, is regulated by the ubiquitin–proteasome system (UPS). The ubiquitination process is tightly controlled by three families of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and finally ubiquitin ligases (E3s). Ubiquitination affects cellular process (apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc.) by regulating the degradation of proteins (via the proteasome and lysosome), coordinating the cellular localization of proteins, activating and inactivating proteins, and modulating protein-protein interactions. The ubiquitin pathway has been implicated in the pathogenesis of several diseases and genetic disorders: cancer, cardiovascular disease, and neurodegenerative disorders, etc. Recent advances in our understanding of the role and molecular mechanisms of UPS components in disease – mainly DUBs and E3 ligases, the development of high-quality chemical tools and novel inhibitors, as well as preclinical studies demonstrating chemical tractability and therapeutic potential – have dramatically taken the ubiquitin proteasome system from an improbable target class, to one of the most robust and exciting arenas for the discovery of novel drugs. TargetMol’s Ubiquitination Compound Library collects 210 ubiquitination related small molecules, targeting proteasome, E1/E2/E3 Enzyme, DUB, p97, etc.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L8600

Ubiquitination Compound Library
sizeIn stock
  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 210 ubiquitination related small chemicals can be used for high throughput and high content screening;
  • Targets include proteasome, E1/E2/E3 Enzyme, DUB, p97, etc.;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

Proteasome
E1/E2/E3 Enzyme
Apoptosis
DUB
p53
Autophagy
DPP-4
Mdm2
NF-κB
Ferroptosis
p97
Cysteine Protease
Antibacterial
Sirtuin
HIV Protease
Dehydrogenase
NEDD8
Mitophagy
PARP
Caspase
IAP
BCL
Epigenetic Reader Domain
IκB/IKK
PROTACs
Antifungal
DNA Alkylator/Crosslinker
PPAR
Aryl Hydrocarbon Receptor
Bcr-Abl
MMP
COX
SARS-CoV
Endogenous Metabolite
Ligand for E3 Ligase
HDAC
Antibiotic
HCV Protease
Src
Amino Acids and Derivatives
p38 MAPK
Factor Xa
Serine Protease
PKC
ERK
RIP kinase
PDE
CDK
NMDAR
Mitochondrial Metabolism
Molecular Glues
Reactive Oxygen Species
JAK
HSV
IGF-1R
HSP
TLR
Aminopeptidase
Neprilysin
Retinoid Receptor
AMPK
TNF
Potassium Channel
Syk
BMI-1
DNA Methyltransferase
TAM Receptor
Protease-activated Receptor
HIF/HIF Prolyl-Hydroxylase

Keywords