Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 42.00 | |
50 mg | In stock | $ 59.00 | |
100 mg | In stock | $ 84.00 | |
200 mg | In stock | $ 138.00 | |
500 mg | In stock | $ 253.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology. |
In vitro | Pranoprofen inhibits ER stress-induced glucose regulated protein 78 (GRP78) expression, an ER-localized molecular chaperon. Pranoprofen inhibits ER stress-induced CCAAT/enhancer-binding protein homologous protein (CHOP) expression, an apoptotic transcription factor. Pranoprofen alone induces eIF2alpha phosphorylation, which is further increased by ER stress. Pranoprofen inhibits ER stress-induced X-box-binding protein 1 (XBP-1) splicing in the primary cultured glial cells. [1] Pranoprofen (0.0625 to 1.0?g/L) has poignant cytotoxicity to human corneal endothelial (HCE) cells, and the extent of its cytotoxicity is dose- and time-dependent. Pranoprofen induces plasma membrane permeability elevation, DNA fragmentation, and apoptotic body formation, proving its apoptosis inducing effect on HCE cells. Pranoprofen above 0.0625?g/L has poignant cytotoxicity on HCE cells in vitro by inducing cell apoptosis, and should be carefully employed in eye clinic. [2] |
In vivo | Pranoprofen is orally administered, urinary and fecal excretions of the radioactivity within 3 days are 81.1% and 18.7% of the dose in mice, 51.5% and 39.4% in rats, 81.8% and 9.0% in guinea pigs, and 93.2% and 3.6% in rabbits, respectively. [3] Pranoprofen is excreted in the urine exclusively in the form of pranoprofen glucuronide in rabbit. Pranoprofen, especially the R(-)-isomer, is significantly distributed in the kidney of rabbit. [4] Pranoprofen has a preference for glucosidation rather than glucuronidation in mice at low doses in spite of having a higher capacity of glucuronidation. [5] |
Synonyms | Pyranoprofen |
Molecular Weight | 255.27 |
Formula | C15H13NO3 |
CAS No. | 52549-17-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 6 mg/mL (23.5 mM)
DMSO: 48 mg/mL (188 mM)
You can also refer to dose conversion for different animals. More
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Pranoprofen 52549-17-4 Apoptosis GPCR/G Protein Immunology/Inflammation Neuroscience COX PGE Synthase Prostaglandin Receptor Prostaglandin E synthase colon cancer keratitis Cyclooxygenase disease ophthalmology inhibit PGE synthase Inhibitor Pyranoprofen NSAID pain prostaglandin ER stress inhibitor