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Pentamidine

Catalog No. T23133 CAS 100-33-4

Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication.

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Pentamidine, CAS 100-33-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 50.00
200 mg	In stock	$ 275.00
500 mg	In stock	$ 523.00

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Purity: 98.13%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication.
Targets&IC50	Leishmania infantum:2.5 μM (IC50)
In vitro	Pentamidine is effective in therapy for the hemolymphatic stage of Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia[1].

Molecular Weight	340.42
Formula	C19H24N4O2
CAS No.	100-33-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Slightly soluble

References and Literature

1. Michael S , Kron M A , Brown R B . Pentamidine: A Review[J]. Reviews of Infectious Diseases(5):625. 2. Carton F , Chevalier Y , Nicoletti L , et al. Rationally designed hyaluronic acid-based nano-complexes for pentamidine delivery[J]. International Journal of Pharmaceutics, 2019, 568:118526.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Inhibitor Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Parasitic Compound Library Anti-Cancer Compound Library Glycometabolism Compound Library FDA-Approved & Pharmacopeia Drug Library

Related Products

Related compounds with same targets

Vutiglabridin PTP1B-IN-22 Etidronic acid 2-Bromo-4'-hydroxyacetophenone LB100 BCI-215 Abyssinone V SC-43

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pentamidine 100-33-4 Metabolism Microbiology/Virology Phosphatase Antifungal Parasite Antibacterial Antibiotic DNA pneumonia Fungal arrest Kidney cell-cycle carinii MP 601205 Bacterial inhibit antitumor MP601205 Pneumocystis Inhibitor biosynthetics PTP1B MP-601205 inhibitor

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