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Nothofagin

Catalog No. TN1996   CAS 11023-94-2

Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases.

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Nothofagin Chemical Structure
Nothofagin, CAS 11023-94-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 489.00
5 mg In stock $ 1,090.00
10 mg In stock $ 1,480.00
25 mg In stock $ 2,230.00
50 mg In stock $ 2,930.00
100 mg In stock $ 3,970.00
1 mL * 10 mM (in DMSO) In stock $ 1,230.00
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Purity: 99.21%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases.
In vitro Pre-treatment of DNPHSA-stimulated RBL-2H3 with 10 μM Nothofagin markedly suppresses the phosphorylation of Lyn, Syk, and Akt. Nothofagin pre-treatment (0.1, 1, 10 μM) decreases the level of histamine release in RBL-2H3 and RPMCs cells. Furthermore, Nothofagin suppresses IgE-mediated mast cell degranulation both in vitro and in vivo [1].
In vivo Oral administration of matrine at 1 mg/kg per day for 7 consecutive days significantly increases the urinary volume of both normotensive (NTR) and spontaneously hypertensive rats (SHR) [2].
Molecular Weight 436.41
Formula C21H24O10
CAS No. 11023-94-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (57.29 mM)

TargetMolReferences and Literature

1. Wonhwa Lee, et al. Anti-inflammatory Effects of Aspalathin and Nothofagin From Rooibos (Aspalathus Linearis) In Vitro and In Vivo. Inflammation. 2015 Aug;38(4):1502-16 2. de Almeida CLB, et al. Prolonged diuretic and saluretic effect of nothofagin isolated from Leandra dasytricha (A. Gray) Cogn. leaves in normotensive and hypertensive rats: Role of antioxidant system and renal protection. Chem Biol Interact. 2018 Jan 5;279:227-233.

Related compound libraries

This product is contained In the following compound libraries:
Kinase Inhibitor Library Natural Product Library Natural Product Library for HTS Antioxidant Compound Library NF-κB Signaling Compound Library Selected Plant-Sourced Compound Library Bioactive Compound Library Anti-Tumor Natural Product Library Polyphenolic Natural Product Library Anti-Obesity Compound Library

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Keywords

Nothofagin 11023-94-2 Apoptosis Immunology/Inflammation MAPK ERK IL Receptor TNF inhibitor inhibit

 

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