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Nothofagin

Catalog No. TN1996 CAS 11023-94-2

Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases.

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Nothofagin, CAS 11023-94-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases.
In vitro	Pre-treatment of DNPHSA-stimulated RBL-2H3 with 10 μM Nothofagin markedly suppresses the phosphorylation of Lyn, Syk, and Akt. Nothofagin pre-treatment (0.1, 1, 10 μM) decreases the level of histamine release in RBL-2H3 and RPMCs cells. Furthermore, Nothofagin suppresses IgE-mediated mast cell degranulation both in vitro and in vivo [1].
In vivo	Oral administration of matrine at 1 mg/kg per day for 7 consecutive days significantly increases the urinary volume of both normotensive (NTR) and spontaneously hypertensive rats (SHR) [2].

Molecular Weight	436.41
Formula	C21H24O10
CAS No.	11023-94-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 25 mg/mL (57.29 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Wonhwa Lee, et al. Anti-inflammatory Effects of Aspalathin and Nothofagin From Rooibos (Aspalathus Linearis) In Vitro and In Vivo. Inflammation. 2015 Aug;38(4):1502-16 2. de Almeida CLB, et al. Prolonged diuretic and saluretic effect of nothofagin isolated from Leandra dasytricha (A. Gray) Cogn. leaves in normotensive and hypertensive rats: Role of antioxidant system and renal protection. Chem Biol Interact. 2018 Jan 5;279:227-233.

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Keywords

Nothofagin 11023-94-2 Apoptosis Immunology/Inflammation MAPK IL Receptor ERK TNF Inhibitor inhibitor inhibit

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