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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12019 | Methylproamine | Others | |
Methylproamine is a DNA-binding radioprotector , acts by repair of transient radiation-induced oxidative species on DNA. | |||
TN1637 | Eurycomalactone | Anti-infection , NF-κB | |
Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-in... | |||
T6878 | LJI308 | S6 Kinase | |
LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. | |||
T9168 | NSC 617145 | NSC617145,NSC-617145 | DNA/RNA Synthesis |
NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. | |||
T6420 | BMS-707035 | HIV Protease | |
BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2. | |||
T5363 | Tempo | 2,2,6,6-Tetramethylpiperidinooxy | Free radical scavengers , Reactive Oxygen Species , DNA/RNA Synthesis , Mitochondrial Metabolism |
Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy. | |||
T24925 | UNC-2170 | UNC2170 Maleate,UNC-2170 Maleate,UNC 2170 Maleate | Others |
UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand. | |||
T6170 | Elesclomol | STA-4783 | Apoptosis , HSP , Reactive Oxygen Species |
Elesclomol (STA-4783) is an oxidative stress inducer and a highly lipophilic copper ion carrier. Elesclomol induces apoptosis in tumor cells and is used in copper death related studies. Elesclomol also inhibits FDX1-medi... | |||
T25390 | Estrandron | ||
Estrandron is an agent containing testosterone, estradiol or their derivatives reported in eastern European literature. | |||
T6116 | Bleomycin Sulfate | Blenoxane,NSC125066 | DNA/RNA Synthesis , Antibiotic |
Bleomycin Sulfate (Blenoxane) is a glycopeptide antibiotic, an inhibitor of DNA synthesis. Bleomycin Sulfate causes DNA strand breaks but not RNA strand breaks. Bleomycin Sulfate has antitumor activity. | |||
T3353 | Niraparib hydrochloride | MK-4827 hydrochloride,MK-4827 (hydrochloride) | Apoptosis , Others , PARP |
Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Niraparib hydrochloride inhibits PARP activity, enhancing the accumulation of... | |||
T9497 | Niraparib tosylate monohyrate | PARP | |
Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting... | |||
T11332 | FUBP1-IN-1 | FUBP1–IN-1 | Others |
FUBP1 - in-1, with an IC50 value of 11.0 M, is an effective FUSE binding protein 1 (FUBP1) inhibitor that can interfere with the binding of FUBP1 to its SINGLE-strand target DNA FUSE sequence. | |||
T14858 | Calicheamicin | Calicheamicin γ1 | Others |
Calicheamicin (Calicheamicin γ1) is an antitumor antibiotic and is a DNA synthesis inhibitor. It also is a cytotoxic agent that causes double-strand DNA breaks. | |||
T6098 | Cabotegravir | GSK744,GSK-1265744,S/GSK1265744 | HIV Protease |
Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM). | |||
T2332 | Elvitegravir | GS-9137,EVG,D06677,JTK-303 | HIV Protease |
Elvitegravir (JTK-303) is a Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor. The mechanism of action of elvitegravir is as an HIV Integrase Inhibitor, and Cytochrome P450 2C9 Inducer. | |||
T8880 | PFM01 | Others | |
PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR). | |||
T1798 | RITA | NSC 652287,RITA (NSC 652287) | Mdm2 , DNA Alkylator/Crosslinker , p53 , Autophagy |
RITA (NSC-652287)(NSC-652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 interaction. | |||
T5780 | HYPOCRELLIN B | Apoptosis , Parasite , Antifungal | |
HYPOCRELLIN B are photosensitive pigments isolated from Hypocrella bambusae Sacc. Hypocrellin B causes DNA strand breakage, induces apoptosis in ovarian cancer cells, and inhibits proliferation of Staphylococcus by incre... | |||
T6588 | Mitoxantrone | mitozantrone | Topoisomerase , PKC |
Mitoxantrone (mitozantrone) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisome... |