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Search Results for " dsb "

20

Compounds

Cat No. Product Name Synonyms Targets
T8880 PFM01 Others
PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR).
T4470 Pyridostatin TFA DNA/RNA Synthesis
Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.
T9760 IC 86621 DNA-PK
IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitumor activity with an EC50 of 68 µM for DNA-PK mediated cell...
T9168 NSC 617145 NSC617145,NSC-617145 DNA/RNA Synthesis
NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner.
T1899 Pyridostatin RR82,Pyridostatin Trifluoroacetate Salt DNA/RNA Synthesis
Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres.
T66152 NDSB-211 Others
NDSB-211 is a surfactant with small hydrophobic ends and mildly solubilizes proteins for protein extraction and analysis.
T19925 EcDsbB-IN-9 Others
EcDsbB-IN-9 is a specific EcDsbB inhibitor, targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria.
T8587 EcDsbB-IN-12 4,5-dichloro-2-[(2-chlorophenyl)methyl]pyridazin-3-one Others
EcDsbB-IN-12 (4,5-dichloro-2-[(2-chlorophenyl)methyl]pyridazin-3-one) targets disulfide bond forming enzyme,and is a novel potent specific inhibitor of EcDsbB.
TF0120 NDSB-201
NDSB-201 is a useful organic compound for research related to life sciences. The catalog number is TF0120 and the CAS number is 15471-17-7.
TF0078 NDSB-195
NDSB-195 is a useful organic compound for research related to life sciences. The catalog number is TF0078 and the CAS number is 160255-06-1.
TF0032 NDSB-256
NDSB-256 is a useful organic compound for research related to life sciences. The catalog number is TF0032 and the CAS number is 81239-45-4.
TF0121 NDSB-221
NDSB-221 is a useful organic compound for research related to life sciences. The catalog number is TF0121 and the CAS number is 160788-56-7.
T8637 DMNB 6-Nitroveratraldehyde DNA-PK
DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human c...
T0987 Gimeracil Gimestat Autophagy
Gimeracil (Gimestat) is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase.
T63228 Simmiparib SMOCL-9112 Apoptosis , PARP
Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR)-deficient...
T68895 CBP-93872
CBP-93872 is a G2 checkpoint inhibitor. CBP-93872 specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint through inhibiting maintenance. CBP-93872 is an inhibitor of maintenance of the DSB-speci...
T68985 Amonafide L-malate
Amonafide L-malate is the malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-s...
T74501 NHEJ inhibitor-1
NHEJ Inhibitor-1 (Compound C2), a trifunctional Pt(II) complex, mitigates non-homologous end joining (NHEJ)/homologous recombination (HR)-related double strand break (DSB) repairs, combating Cisplatin resistance in non-s...
T61017 Topoisomerase II inhibitor 6
Topoisomerase II inhibitor 6 (Compound 5) is a tryptanthrin derivative. Topoisomerase II inhibitor 6 is a potent and selective topoisomerase II inhibitor. Topoisomerase II inhibitor 6 blocks the CCRF-CEM cell cycle in th...
T78747 DiPT-4 Topoisomerase
DiPT-4, a dual TOP1/PARP1 inhibitor, effectively induces DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells, with potential to circumvent drug resistance [1].
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