20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8880 | PFM01 | Others | |
PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR). | |||
T4470 | Pyridostatin TFA | DNA/RNA Synthesis | |
Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2. | |||
T9760 | IC 86621 | DNA-PK | |
IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitumor activity with an EC50 of 68 µM for DNA-PK mediated cell... | |||
T9168 | NSC 617145 | NSC617145,NSC-617145 | DNA/RNA Synthesis |
NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. | |||
T1899 | Pyridostatin | RR82,Pyridostatin Trifluoroacetate Salt | DNA/RNA Synthesis |
Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. | |||
T66152 | NDSB-211 | Others | |
NDSB-211 is a surfactant with small hydrophobic ends and mildly solubilizes proteins for protein extraction and analysis. | |||
T19925 | EcDsbB-IN-9 | Others | |
EcDsbB-IN-9 is a specific EcDsbB inhibitor, targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria. | |||
T8587 | EcDsbB-IN-12 | 4,5-dichloro-2-[(2-chlorophenyl)methyl]pyridazin-3-one | Others |
EcDsbB-IN-12 (4,5-dichloro-2-[(2-chlorophenyl)methyl]pyridazin-3-one) targets disulfide bond forming enzyme,and is a novel potent specific inhibitor of EcDsbB. | |||
TF0120 | NDSB-201 | ||
NDSB-201 is a useful organic compound for research related to life sciences. The catalog number is TF0120 and the CAS number is 15471-17-7. | |||
TF0078 | NDSB-195 | ||
NDSB-195 is a useful organic compound for research related to life sciences. The catalog number is TF0078 and the CAS number is 160255-06-1. | |||
TF0032 | NDSB-256 | ||
NDSB-256 is a useful organic compound for research related to life sciences. The catalog number is TF0032 and the CAS number is 81239-45-4. | |||
TF0121 | NDSB-221 | ||
NDSB-221 is a useful organic compound for research related to life sciences. The catalog number is TF0121 and the CAS number is 160788-56-7. | |||
T8637 | DMNB | 6-Nitroveratraldehyde | DNA-PK |
DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human c... | |||
T0987 | Gimeracil | Gimestat | Autophagy |
Gimeracil (Gimestat) is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase. | |||
T63228 | Simmiparib | SMOCL-9112 | Apoptosis , PARP |
Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR)-deficient... | |||
T68895 | CBP-93872 | ||
CBP-93872 is a G2 checkpoint inhibitor. CBP-93872 specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint through inhibiting maintenance. CBP-93872 is an inhibitor of maintenance of the DSB-speci... | |||
T68985 | Amonafide L-malate | ||
Amonafide L-malate is the malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-s... | |||
T74501 | NHEJ inhibitor-1 | ||
NHEJ Inhibitor-1 (Compound C2), a trifunctional Pt(II) complex, mitigates non-homologous end joining (NHEJ)/homologous recombination (HR)-related double strand break (DSB) repairs, combating Cisplatin resistance in non-s... | |||
T61017 | Topoisomerase II inhibitor 6 | ||
Topoisomerase II inhibitor 6 (Compound 5) is a tryptanthrin derivative. Topoisomerase II inhibitor 6 is a potent and selective topoisomerase II inhibitor. Topoisomerase II inhibitor 6 blocks the CCRF-CEM cell cycle in th... | |||
T78747 | DiPT-4 | Topoisomerase | |
DiPT-4, a dual TOP1/PARP1 inhibitor, effectively induces DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells, with potential to circumvent drug resistance [1]. |