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NBD-556

Catalog No. T16276 CAS 333353-44-9

NBD-556 is a small molecule mimetic of CD4. NBD-556 recognizes the HIV-1 envelope protein gp120 and induces restructuring of gp120 analogous to CD4 binding.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

NBD-556, CAS 333353-44-9

Pack Size	Availability	Price/USD
2 mg	In stock	$ 34.00
5 mg	In stock	$ 55.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 162.00
50 mg	In stock	$ 238.00
100 mg	In stock	$ 358.00
200 mg	In stock	$ 528.00
1 mL * 10 mM (in DMSO)	In stock	$ 61.00

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Purity: 99.76%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

NBD-556 is a small molecule mimetic of CD4. NBD-556 recognizes the HIV-1 envelope protein gp120 and induces restructuring of gp120 analogous to CD4 binding.

In vitro

HIV NBD-556 N-phenyl-N′-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamide analogs as a novel class of human immunodeficiency virus type 1 (HIV-1) entry inhibitors that block the gp120–CD4 interaction. The small molecule NBD-556 mimics CD4 by binding the gp120 exterior envelope glycoprotein, moderately inhibiting virus entry into CD4-expressing target cells, and enhancing CCR5 binding and virus entry into CCR5-expressing cells lacking CD4.

Molecular Weight	337.84
Formula	C17H24ClN3O2
CAS No.	333353-44-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 33.33 mg/mL (98.66 mM), Sonification is recommended.

References and Literature

1. Narumi, Tetsuo et al. CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist. Bioorganic & Medicinal Chemistry Letters (2010), 20(19), 5853-5858. 2. Schon A, et al. Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120. Biochemistry. 2006 Sep 12;45(36):10973-10980. 3. Singh IP, Chauthe SK. Small molecule HIV entry inhibitors: Part II. Attachment and fusion inhibitors: 2004-2010. Expert Opin Ther Pat. 2011 Mar;21(3):399-416. 4. Zhao Q, Ma L, Jiang S, Lu H, Liu S, He Y, Strick N, Neamati N, Debnath AK. Identification of N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4. Virology. 2005 Sep 1;339

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max NO PAINS Compound Library ReFRAME Related Library PPI Inhibitor Library Bioactive Compound Library Anti-Infection Compound Library Anti-Viral Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NBD-556 333353-44-9 Microbiology/Virology Proteases/Proteasome HIV Protease inhibit HIV-1 fusion virus-cell Human immunodeficiency virus HIV NBD 556 Inhibitor NBD556 gp120 CD4 mimetic inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.