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Mito-LND

Catalog No. T9211   CAS 2361564-49-8
Synonyms: Mito-Loidamine

Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.

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Mito-LND Chemical Structure
Mito-LND, CAS 2361564-49-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 135.00
2 mg In stock $ 193.00
5 mg In stock $ 289.00
10 mg In stock $ 478.00
25 mg In stock $ 789.00
50 mg In stock $ 1,080.00
100 mg In stock $ 1,480.00
1 mL * 10 mM (in DMSO) In stock $ 423.00
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Purity: 98.23%
Purity: 97.27%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.
In vitro Mito-LND inhibits cell growth of H2030BrM3 and A549 cells with IC50 of 0.74 μM and 0.69?μM, respectively. Mito-LND inhibits mitochondrial complex I and II activities with IC50 of 1.2 μM and 2.4?μM, respectively in H2030BrM3 cells. Mito-LND potently induces mitochondrial ROS generation in H2030BrM3 lung cancer cells. Mito-LND decreases the levels of phosphorylated AKT. Mito-LND also decreases the phosphorylation of P70S6K and other energy-sensing proteins in both the parental and metastatic lung cancer cell lines, indicating that Mito-LND specifically downregulates mTOR signaling.
In vivo Mito-LNDtreatment markedly enhanced potency against both lung cancer progression and metastasis. Mito-LND also decreases the rate of growth of A549 tumor xenografts. Mito-LND treatment shows a marked decrease in lung cancer brain metastasis in NOD/SCID mice bearing H2030BrM3 cells.
Synonyms Mito-Loidamine
Molecular Weight 801.62
Formula C43H45BrCl2N3OP
CAS No. 2361564-49-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45mg/ml(56.14mM), sonification is recommended.

TargetMolReferences and Literature

1. Cheng G , Zhang Q , Pan J , et al. Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis[J]. Nature Communications, 2019, 10(1).

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library NO PAINS Compound Library Anti-Prostate Cancer Compound Library Bioactive Compounds Library Max Anti-Aging Compound Library Anti-Breast Cancer Compound Library Immunology/Inflammation Compound Library Inhibitor Library Antioxidant Compound Library Bioactive Compound Library

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Keywords

Mito-LND 2361564-49-8 Apoptosis Autophagy Immunology/Inflammation Metabolism NF-Κb Mitochondrial Metabolism OXPHOS Reactive Oxygen Species Mito-Lonidamine mTOR Mito-Loidamine p70S6K oxidative MitoLND Inhibitor inhibit mitochondria Mito LND anti-invasive anti-cancer phosphorylation AKT inhibitor

 

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