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Mito-LND

Catalog No. T9211   CAS 2361564-49-8
Synonyms: Mito-Loidamine

Mito-LND is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.

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Mito-LND, CAS 2361564-49-8
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Purity 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Mito-LND is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.
In vitro Mito-LND inhibits cell growth of H2030BrM3 and A549 cells with IC50 of 0.74 μM and 0.69?μM, respectively. Mito-LND inhibits mitochondrial complex I and II activities with IC50 of 1.2 μM and 2.4?μM, respectively in H2030BrM3 cells. Mito-LND potently induces mitochondrial ROS generation in H2030BrM3 lung cancer cells. Mito-LND decreases the levels of phosphorylated AKT. Mito-LND also decreases the phosphorylation of P70S6K and other energy-sensing proteins in both the parental and metastatic lung cancer cell lines, indicating that Mito-LND specifically downregulates mTOR signaling.
In vivo Mito-LNDtreatment markedly enhanced potency against both lung cancer progression and metastasis. Mito-LND also decreases the rate of growth of A549 tumor xenografts. Mito-LND treatment shows a marked decrease in lung cancer brain metastasis in NOD/SCID mice bearing H2030BrM3 cells.
Synonyms Mito-Loidamine
Molecular Weight 801.62
Formula C43H45BrCl2N3OP
CAS No. 2361564-49-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 45mg/ml(56.14mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Cheng G , Zhang Q , Pan J , et al. Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis[J]. Nature Communications, 2019, 10(1).

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.