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MPTP hydrochloride

Catalog No. T4081 CAS 23007-85-4

Synonyms: MPTP-hydrochloride

MPTP hydrochloride is a precursor of MPP+, a dopamine neurotoxin with blood-brain barrier permeability. MPTP hydrochloride is toxic to dopaminergic neurons, which can lead to Parkinson's disease, and is widely used in the construction of animal models of Parkinson's disease.

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MPTP hydrochloride, CAS 23007-85-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 30.00
10 mg	In stock	$ 48.00
25 mg	In stock	$ 89.00
50 mg	In stock	$ 148.00
100 mg	In stock	$ 207.00
200 mg	In stock	$ 329.00
500 mg	In stock	$ 555.00
1 g	In stock	$ 798.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

Purity: 99.73%

Purity: 99.65%

Purity: 99.4%

Purity: 96.35%

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Description	MPTP hydrochloride is a precursor of MPP+, a dopamine neurotoxin with blood-brain barrier permeability. MPTP hydrochloride is toxic to dopaminergic neurons, which can lead to Parkinson's disease, and is widely used in the construction of animal models of Parkinson's disease.
In vitro	METHODS: Human neuroblastoma cells M17 were treated with MPTP hydrochloride (1-50 μM) for 48 h. The expression levels of target proteins were detected by Western Blot. RESULTS: MPTP hydrochloride promoted Tau protein phosphorylation in M17 cells. [1] METHODS: Neuroblastoma cell N2AB-1 and glioma cell C6 were treated with MPTP hydrochloride (0.33-33.7 μM) for 24 h, and the growth curves were examined. RESULTS: MPTP hydrochloride did not affect the cell number of actively growing N2AB-1 or C6 cells. [2]
In vivo	METHODS: To construct a subacute Parkinson's model, MPTP hydrochloride (30 mg/kg in 0.9% saline) was administered intraperitoneally to C57BL/6 mice once daily for five days. RESULTS: Subacute MPTP hydrochloride treatment did not cause significant motor deficits, although the dopaminergic system was severely impaired. mPTP hydrochloride significantly increased the level of α-synuclein and the number of astrocytes in the striatum and disrupted the blood-brain barrier in the substantia nigra pars compacta. [3] METHODS: To study the effects of different models on the behavior and pathology of a mouse model of Parkinson's disease, MPTP hydrochloride was used intraperitoneally to construct a subacute model group and a chronic model group. In the subacute model group, MPTP hydrochloride (30 mg/kg) was administered once daily for ten days. In the chronic model group, MPTP hydrochloride (30 mg/kg) was injected once every 3.5 days for five weeks for ten times. RESULTS: In the MPTP hydrochloride-induced subacute Parkinson's disease mouse model, there was a small loss of dopaminergic neurons in the midbrain, but there was no effect on the behavior.The MPTP hydrochloride-induced chronic Parkinson's disease mouse model lost a large number of dopaminergic neurons, which was accompanied by anxiety-like behaviors in addition to motor dysfunction. [4]

Synonyms	MPTP-hydrochloride
Molecular Weight	209.72
Formula	C12H16ClN
CAS No.	23007-85-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10mg/mL

DMSO: 5 mg/mL (23.84 mM)

References and Literature

1. Qureshi HY, et al. Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro. J Biol Chem. 2011 Feb 18;286(7):5055-68. 2. Notter MF, et al. Neurotoxicity of MPTP and MPP+ in vitro: characterization using specific cell lines. Brain Res. 1988 Jul 26;456(2):254-62. 3. Zhang QS, et al. Reassessment of subacute MPTP-treated mice as animal model of Parkinson's disease. Acta Pharmacol Sin. 2017 Oct;38(10):1317-1328. 4. Ma Y, et al. Effect of Different MPTP Administration Intervals on Mouse Models of Parkinson's Disease. Contrast Media Mol Imaging. 2022 Mar 2;2022:2112146.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library GPCR Compound Library Anti-Neurodegenerative Disease Compound Library Ferroptosis Compound Library Anti-Cancer Compound Library Endocrinology-Hormone Compound Library CNS-Penetrant Compound Library Anti-Aging Compound Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library

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Keywords

MPTP hydrochloride 23007-85-4 Apoptosis GPCR/G Protein Neuroscience Dopamine Receptor MPTP-hydrochloride brain Inhibitor Parkinson’s inhibit Disease neurotoxin MPTP MPTP Hydrochloride penetrant inhibitor

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