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MF-766

Catalog No. T9622 CAS 1050656-06-8

MF-766 is a highly potent, selective and orally active EP4 antagonist with a Ki of 0.23 nM. It behaves as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay. It can be used for cancer and inflammation diseases research[1][2].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MF-766, CAS 1050656-06-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 74.00
5 mg	In stock	$ 178.00
10 mg	In stock	$ 289.00
25 mg	In stock	$ 572.00
50 mg	In stock	$ 822.00
100 mg	In stock	$ 1,130.00
500 mg	In stock	$ 2,280.00
1 mL * 10 mM (in DMSO)	In stock	$ 193.00

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Biological Description

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Description	MF-766 is a highly potent, selective and orally active EP4 antagonist with a Ki of 0.23 nM. It behaves as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay. It can be used for cancer and inflammation diseases research[1][2].
Targets&IC50	EP4:0.23 nM (Ki)
In vitro	MF-766, at concentrations ranging from 0.01 to 10 μM and pretreated for 1 hour before being stimulated with 50 ng/mL IL-2—both with and without 0.33 μM PGE2 for 18 hours—effectively reverses the suppression of IFN-γ secretion in human NK cells caused by PGE2. Importantly, the viability of NK cells remains unaffected by MF-766[2].
In vivo	MF-766 (oral gavage; 30 mg/kg; once daily; 21 days) exhibits TGI% of 49% in CT26 tumor model. But it does not exhibits significant difference in EMT6 and 4T1 tumor model[2]. MF-766 (oral gavage; 30 mg/kg combination with anti-PD-1 mDX400; once daily; 21 days; q4dx8) shows potent anti-tumor activities in different preclinical models. The % of TGI are 89%, 66% and 40%, respectively in CT26 tumor, EMT6 and 4T1 tumor model[2].

Molecular Weight	478.46
Formula	C27H21F3N2O3
CAS No.	1050656-06-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (104.50 mM), Sonication is recommended.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Membrane Protein-targeted Compound Library GPCR Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Bioactive Compound Library Orally Active Compound Library

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Related compounds with same targets

Tranilast Shizukaol B Vidupiprant Terutroban Carboprost tromethamine mPGES1-IN-3 6-Dehydrogingerdione Eupatolide

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MF-766 1050656-06-8 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor EP4 arthritis inflammation disease AIA inhibit anti-tumor MF766 MF 766 Inhibitor cancer inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.