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Target-Focused Phenotypic Screening Library

Catalog No. L9500
  Library Compound List   Excel SDF

TargetMol offers a high quality Target-focused Phenotypic Screening Library (1796 compounds in total) with maximal biological and chemical diversity for such empirical approaches. Phenotypic approaches use semi-empirical methods that do not require much knowledge of the target and understanding of the mechanism. A recent analysis revealed the phenotypic approaches to be the more successful strategy for small-molecule, first-in-class medicines. The rationalization for this success was the unbiased identification of the molecular mechanism of action (MMOA). In addition, an understanding of mechanism is not required for regulatory approval; the regulatory agencies are less concerned with the MMOA of a compound than with whether it is effective. It can be argued that in seeking the best path to new medicines, academic science should be focusing not on gene-based, hypothesis-driven research but on translating disease knowledge into disease-relevant phenotypic assays for screening and chemical biology approaches to screening and target identification as well as on systematic approaches to understanding the MMOA. Greater focus on translational research should lead to greater access to more reliable phenotypic assays.

Use of well-annotated bioactive compounds with clear targets for phenotypic screening can also narrow the scope of targets that are needed to be validated, therefore, it is an effective tool for target identification or validation.

Given the potential applications of a Phenotypic Screening Library, the focus of the compounds selection strategy lies on biodiversity and maximal coverage of chemical space, aimed at providing hits for a wide spectrum of biological goals. This library finally was developed to contain a set of compounds with confirmed biological activity for more than 600 drug targets and includes 2-4 structurally diverse compounds for each target.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Compound Libraries | TargetMol
Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
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Product Description

  • A unique collection of 1796 annotated bioactive compounds with clear targets, suitable for phenotypic screening;
  • Cover more than 600 drug targets, Structurally diverse;
  • 2-4 structurally diversified compounds for the same annotated 'on-target' to increase the success rate of target identification (enables the generation of much stronger target–phenotype hypotheses);
  • Detailed information about compound structure, target, activity, etc.;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L9500)

Publications Cited TargetMol Libraries

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Library Composition

Apoptosis (266)
Autophagy (255)
Endogenous Metabolite (89)
Antibacterial (87)
5-HT Receptor (69)
Antibiotic (55)
AChR (51)
DNA/RNA Synthesis (49)
Adrenergic Receptor (47)
P450 (45)
VEGFR (44)
Dopamine Receptor (42)
HIV Protease (40)
Epigenetic Reader Domain (36)
PI3K (36)
PDE (34)
FGFR (32)
Histamine Receptor (31)
Influenza Virus (31)
COX (31)
CDK (30)
PDGFR (30)
Parasite (29)
Ferroptosis (29)
FLT (28)
NF-κB (28)
c-Kit (27)
Src (27)
TRP/TRPV Channel (26)
Potassium Channel (26)
Raf (24)
GluR (24)
EGFR (23)
PPAR (23)
Histone Methyltransferase (23)
Calcium Channel (23)
Dehydrogenase (23)
HCV Protease (23)
JAK (22)
Mitophagy (22)
HDAC (21)
Reactive Oxygen Species (21)
TGF-beta/Smad (21)
Microtubule Associated (20)
SARS-CoV (20)
BCL (20)
mTOR (19)
Topoisomerase (19)
Adenosine Receptor (19)
GABA Receptor (18)
Bcr-Abl (18)
c-Met/HGFR (18)
GPR (18)
Estrogen/progestogen Receptor (18)
PKC (17)
Beta Amyloid (17)
MAO (17)
p38 MAPK (17)
Antifungal (17)
RAAS (16)
IL Receptor (16)
IκB/IKK (15)
Retinoid Receptor (15)
Wnt/beta-catenin (15)
TNF (15)
ALK (15)
Carbonic Anhydrase (15)
Proteasome (15)
Sodium Channel (15)
E1/E2/E3 Enzyme (15)
MMP (15)
Virus Protease (14)
GSK-3 (14)
Monoamine Oxidase (14)
STAT (14)
Prostaglandin Receptor (14)
Estrogen Receptor/ERR (14)
Opioid Receptor (14)
ATPase (13)
HIF/HIF Prolyl-Hydroxylase (13)
Aurora Kinase (13)
ERK (13)
ROR (13)
Gamma-secretase (13)
Akt (13)
CXCR (12)
Interleukin (12)
Sirtuin (12)
HSV (12)
c-RET (12)
Phosphatase (12)
DNA Alkylator/Crosslinker (12)
NADPH (12)
DNA Alkylation (11)
Caspase (11)
PKA (11)
Lipoxygenase (11)
NMDAR (11)
Trk receptor (11)
PARP (11)
HSP (11)
Nucleoside Antimetabolite/Analog (11)
MEK (11)
iGluR (11)
HIF (10)
Nrf2 (10)
DUB (10)
Indoleamine 2,3-Dioxygenase (IDO) (10)
DNA Methyltransferase (10)
Chk (10)
S1P Receptor (10)
JNK (10)
Casein Kinase (10)
Hedgehog/Smoothened (10)
ROCK (10)
ribosome (10)
Serine Protease (10)
Glucocorticoid Receptor (10)
LPL Receptor (9)
Serine/threonin kinase (9)
Serotonin Transporter (9)
ATM/ATR (9)
AMPK (9)
CaMK (9)
Reverse Transcriptase (9)
Phospholipase (9)
Norepinephrine (9)
Cannabinoid Receptor (9)
SGLT (9)
P-gp (9)
P2Y Receptor (9)
DNA-PK (8)
Cysteine Protease (8)
AChE (8)
HER (8)
p53 (8)
CFTR (8)
Transferase (8)
TLR (8)
Endothelin Receptor (8)
Ras (8)
PLK (8)
c-Fms (8)
HBV (8)
Syk (8)
S6 Kinase (8)
TAM Receptor (7)
HMG-CoA Reductase (7)
CCR (7)
Thyroid hormone receptor(THR) (7)
Reductase (7)
Glucokinase (7)
Drug Metabolite (7)
Proton pump (7)
NOS (7)
Monocarboxylate transporter (7)
Acyltransferase (6)
Aryl Hydrocarbon Receptor (6)
Histone Acetyltransferase (6)
Rho (6)
Tyrosine Kinases (6)
Aromatase (6)
PDK (6)
Mitochondrial Metabolism (6)
BTK (6)
Lipase (6)
NOD (6)
PKM (6)
OX Receptor (6)
Mdm2 (6)
ROS (6)
FAK (6)
Smo (6)
Sigma receptor (6)
PD-1/PD-L1 (5)
IDO (5)
LRRK2 (5)
NAMPT (5)
Chloride channel (5)
AhR (5)
FXR (5)
FAAH (5)
Factor Xa (5)
Glutathione Peroxidase (5)
PERK (5)
MAPK (5)
DHFR (5)
PAK (5)
Kinesin (5)
DPP-4 (5)
Androgen Receptor (5)
DNA gyrase (5)
Telomerase (5)
ATP Citrate Lyase (5)
IGF-1R (5)
Phosphorylase (5)
Histone Demethylase (4)
transporter (4)
BMI-1 (4)
LTR (4)
PAI-1 (4)
BACE (4)
Melatonin Receptor (4)
cAMP (4)
Glucosidase (4)
GPCR19 (4)
Acetyl-CoA Carboxylase (4)
Tie-2 (4)
Progesterone Receptor (4)
DNA (4)
MRP (4)
CaSR (4)
Ephrin Receptor (4)
ABC (4)
CSF-1R (4)
RIP kinase (4)
PGE Synthase (4)
NO Synthase (4)
Annexin A (4)
MNK (4)
Fatty Acid Synthase (4)
Lipid (4)
IRE1 (4)
NOD-like Receptor (NLR) (4)
Tyrosinase (4)
Xanthine Oxidase (4)
Porcupine (4)
p97 (4)
Monoamine Transporter (4)
CAT (4)
Na+/Ca2+ Exchanger (3)
c-Myc (3)
advanced glycation end products (3)
UGT (3)
ACK (3)
PTEN (3)
Hydroxylase (3)
Neurokinin receptor (3)
IRAK (3)
CETP (3)
DprE1 (3)
Neprilysin (3)
Leukotriene Receptor (3)
Survivin (3)
Pim (3)
STING (3)
Free radical scavengers (3)
P2X Receptor (3)
RSV (3)
Liver X Receptor (3)
LIM Kinase (3)
GNRH Receptor (3)
Gap Junction Protein (2)
Pyroptosis (2)
GluCls (2)
Antioxidant (2)
YAP (2)
Wee1 (2)
NADPH-oxidase (2)
Vasopressin Receptor (2)
Ligands for Target Protein for PROTAC (2)
GRK (2)
Integrin (2)
PAFR (2)
LDL (2)
Thrombin (2)
Antiviral (2)
MT Receptor (2)
IFNAR (2)
MTH1 (2)
LPA Receptor (2)
PI4K (2)
Stearoyl-CoA Desaturase (SCD) (2)
CRISPR/Cas9 (2)
BCRP (2)
GlyT (2)
Beta-Secretase (2)
PGC-1α (2)
Carboxypeptidase (2)
Antifolate (2)
MLK (2)
Myosin (2)
Cell wall (2)
DYRK (2)
Antifection (2)
Protease-activated Receptor (2)
ROS Kinase (1)
Neuropeptide Y Receptor (1)
Molecular Glues (1)
IAP (1)
Adenylyl cyclase (1)
Ligand for E3 Ligase (1)
lysosomal autophagy (1)
Hck (1)
OCT (1)
GPX (1)
VDA (1)
Na-K-Cl cotransporter (1)
GST (1)
Hippo pathway (1)
Adenosine deaminase (1)
PAD (1)
SGK (1)
Discoidin Domain Receptor (DDR) (1)
ASK (1)
Arginase (1)
Amino Acids and Derivatives (1)
Aminopeptidase (1)
Anti-infection (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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