Home Tools

Loratadine

Catalog No. T1097 CAS 79794-75-5

Synonyms: SCH 29851, Loratidine

Loratadine (SCH 29851) is a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Loratadine, CAS 79794-75-5

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 41.00

Bulk Inquiry

Select Batch

Purity: 99.75%

Purity: 99.49%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Loratadine (SCH 29851) is a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
Targets&IC50	B(0)AT2:4 μM
In vivo	Loratadine blocks Kv1.5 channels in a concentration-, voltage-, time-, and use-dependent manner when expressed in human Ltk-cells transfected with the hKv1.5 channel gene at concentrations exceeding therapeutic plasma levels. It also inhibits rhinovirus-induced upregulation of ICAM-1 in main bronchial or transformed respiratory epithelial cells. Identified as a selective inhibitor of B(0)AT 2 with an IC50 of 4 μM, loratadine exhibits low or no activity against several other members of the SLC6 family. Pre-incubation with loratadine concentration-dependently suppresses the release of histamine and LTC4 in human FcεRI+ cells upon challenge with Der p1 antigen or anti-FcεRI. In human umbilical vein endothelial cells, loratadine significantly inhibits histamine-induced secretion of IL-6 and IL-8, with its active metabolites showing even stronger effects. Additionally, loratadine in a dose-dependent manner inhibits the mRNA of ICAM-1 induced by rhinovirus infection and completely suppresses the activation of the rhinovirus-induced ICAM-1 promoter.

Synonyms	SCH 29851, Loratidine
Molecular Weight	382.88
Formula	C22H23ClN2O2
CAS No.	79794-75-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 77 mg/mL (201.1 mM)

DMSO: 17 mg/mL (44.4 mM)

References and Literature

1. Cuboni S, et al. J Med Chem, 2014, 57(22), 9473-9479. 2. Genovese A, et al. Clin Exp Allergy, 1997, 27(5), 559-567. 3. Molet S, et al. Clin Exp Allergy, 1997, 27(10), 1167-1174. 4. Delpón E, et al. Cardiovasc Res. 1997 Aug;35(2):341-50. 5. Papi A, et al. J Allergy Clin Immunol, 2001, 108(2), 221-228.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Inhibitor Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library NO PAINS Compound Library Bioactive Compounds Library Max Clinical Compound Library Pediatric Drug Library

Related Products

Related compounds with same targets

Koaburaside Oseltamivir phosphate Coptisine chloride Trifluoperazine Filixic acid ABA Tofacitinib Citrate Hyperoside Amitivir

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Loratadine 79794-75-5 GPCR/G Protein Immunology/Inflammation Microbiology/Virology Neuroscience Influenza Virus Histamine Receptor SCH-29851 inhibit SCH29851 SCH 29851 Inhibitor Loratidine inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.