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Licostinel

Catalog No. T27828 CAS 153504-81-5

Synonyms: CGP 63446, ACEA1021, ACEA 1021, ACEA-1021, CGP-63446

Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.

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Licostinel, CAS 153504-81-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 55.00
10 mg	In stock	$ 87.00
25 mg	In stock	$ 183.00
50 mg	In stock	$ 297.00
100 mg	In stock	$ 443.00
1 mL * 10 mM (in DMSO)	In stock	$ 58.00

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Purity: 98.02%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.

Synonyms	CGP 63446, ACEA1021, ACEA 1021, ACEA-1021, CGP-63446
Molecular Weight	276.03
Formula	C8H3Cl2N3O4
CAS No.	153504-81-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (199.25 mM)

References and Literature

1. Qiu W, Wei R, Zhang C, Zhang C, Leng W, Wang W. A glycine site-specific NMDA receptor antagonist protects retina ganglion cells from ischemic injury by modulating apoptotic cascades. J Cell Physiol. 2010 Jun;223(3):819-26. doi: 10.1002/jcp.22118. PubMed PMID: 20333677. 2. Cai SX. Glycine/NMDA receptor antagonists as potential CNS therapeutic agents: ACEA-1021 and related compounds. Curr Top Med Chem. 2006;6(7):651-62. PubMed PMID: 16719807. 3. Petty MA, Weintraub PM, Maynard KI. ACEA 1021: flip or flop? CNS Drug Rev. 2004 Winter;10(4):337-48. Review. PubMed PMID: 15592582. 4. Wiley JL, Balster RL. Effects of modulators of N-methyl-D-aspartate receptor-mediated neurotransmission on diazepam discrimination in rats. Life Sci. 2004 May 28;75(2):141-51. PubMed PMID: 15120567.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Membrane Protein-targeted Compound Library Anti-Neurodegenerative Disease Compound Library Bioactive Compounds Library Max ReFRAME Related Library Bioactive Compound Library Neuronal Signaling Compound Library

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Related compounds with same targets

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Licostinel 153504-81-5 Neuroscience GluR CGP 63446 ACEA1021 ACEA 1021 ACEA-1021 CGP-63446 CGP63446 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.