Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JHU37152 (JHU 37152) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 80.00 | |
10 mg | In stock | $ 139.00 | |
25 mg | In stock | $ 288.00 | |
50 mg | In stock | $ 448.00 | |
100 mg | In stock | $ 658.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 89.00 |
Description | JHU37152 (JHU 37152) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively. |
Targets&IC50 | M3Dq DREADD (human):5 nM (EC50), M4Di DREADD (human):0.5 nM (EC50) |
In vitro | JHU 37152 is a potent DREADD agonist with high potency and efficacy in fluorescent and BRET-based assays in HEK-293 cells, whereas no responses are observed in untransfected HEK-293 cells |
In vivo | JHU 37152 exhibits high in vivo DREADD potency. JHU37152 exhibits selective [3H]clozapine displacement from DREADDs in brain tissue from WT and D1-DREADD mice |
Synonyms | JHU 37152 |
Molecular Weight | 358.84 |
Formula | C19H20ClFN4 |
CAS No. | 2369979-67-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 72 mg/mL (200.65 mM)
Ethanol: 24 mg/mL (66.88 mM)
You can also refer to dose conversion for different animals. More
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JHU37152 2369979-67-7 Neuroscience AChR inhibit hM3Dq Clozapine Inhibitor JHU-37152 DREADD JHU 37152 Muscarinic acetylcholine receptor mAChR hM4Di inhibitor