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Search Results for " machr "

20

Compounds

Cat No. Product Name Synonyms Targets
T5655 mAChR-IN-1 hydrochloride AChR
mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 Nm.
T9889 M4 mAChR agonist-1  4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)- AChR
M4 mAChR agonist-1 (4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-) is an effective agonist of M4 mAChR (EC50 >10 μM).
T5476 mAChr-in-1 AChR
mAChR-IN-1 is muscarinic cholinergic receptor(mAChR) antagonist (IC50=17 nM).
T81888 mAChR antagonist 1
Compound 4a, a mAChR antagonist, exhibits K i values of 255 nM for M1 and M5 subtypes, and lower values of 121 nM and 158 nM for M3 and M4 subtypes, respectively [1].
T1760 TBPB AChR
TBPB is an allosteric M1 mAChR agonist.
T7555 Piperidolate hydrochloride AChR
Piperidolate hydrochloride is an antimuscarinic, could restrain the abnormal activity caused by acetylcholine. inhibits intestinal cramp induced by acetylcholine (rats and dogs).
T23116 Oxotremorine sesquifumarate AChR
Oxotremorine sesquifumarate is a muscarinic agonist.
T11078 Deschloroclozapine Serotonin Transporter
Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively.
T8196 Arborine Arborin Others , AChR
Arborine (Arborin) is a larval growth inhibitor from glycoslnis pentaphylla.
T6575 LY2119620 AChR
LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.
T13325 VU 0365114 AChR
VU 0365114 is a positive allosteric modulator of mAChR M5 (EC50: 2.7 μM).
T6548 Irsogladine Dicloguamine PDE , AChR
Irsogladine (Dicloguamine) is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
T17244 VU0467154 AChR
VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor. The response to ACh with pEC50s of 7.75, 6.2, and 6 for a rat, human, and cynomolgus monkey M4 receptor, respectively.
T7405 Piperidolate AChR
Piperidolate inhibits intestinal cramp induced by acetylcholine
T8219 VU0238441 AChR
VU0238441 is agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM.
T13066 TAK-071 AChR
TAK-071 is a potent, novel and highly selective modulator of muscarinic acetylcholine receptor 1 (M1R) positive allosteric(EC50 : 520 nM).
T9420 Prifinium bromide Others
Prifinium bromide is a quaternary ammon antimuscarinic. It inhibits hyperkinesia of the digestive organs and urinary tract and has a spasmolytic action.
T4997 Umeclidinium bromide GSK573719A AChR
Umeclidinium bromide (GSK573719A) is a novel mAChR antagonist.
T3993 BQCA benzylquinolone carboxylic acid AChR
BQCA (benzylquinolone carboxylic acid) a highly selective allosteric M1 mAChR modulator.
T8224 VU0119498 AChR
VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.
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