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Sulfoxaflor

Name: Sulfoxaflor
Brand: TargetMol
SKU: T19940
Price: 107 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19940Cas No. 946578-00-3

Alias XDE 208, GF 2372, GF 2032

Sulfoxaflor (GF 2032) is an agonist of nAChR1 and nAChR2 subtypes and a systemic insecticide that acts on the insect central nervous system. Sulfoxaflor was found to have some effects on peripheral blood lymphocytes and is used to control sap-feeding insects such as brown planthopper, whitefly, peach aphid, and cotton aphid.

Sulfoxaflor

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Purity: 99.98%

Catalog No. T19940Alias XDE 208, GF 2372, GF 2032Cas No. 946578-00-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$107	In Stock	In Stock
5 mg	$306	In Stock	In Stock
10 mg	$427	In Stock	In Stock
25 mg	$636	In Stock	In Stock
50 mg	$867	-	In Stock
100 mg	$1,130	-	In Stock
1 mL x 10 mM (in DMSO)	$273	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.98%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Sulfoxaflor (GF 2032) is an agonist of nAChR1 and nAChR2 subtypes and a systemic insecticide that acts on the insect central nervous system. Sulfoxaflor was found to have some effects on peripheral blood lymphocytes and is used to control sap-feeding insects such as brown planthopper, whitefly, peach aphid, and cotton aphid.
In vitro	METHODS: Blood lymphocytes were treated with Sulfoxaflor (GF 2032) (10 µg/mL, 20 µg/mL, 40 µg/mL), and single cell gel electrophoresis (comet electrophoresis), cytokinesis block micronucleus assay (MN assay), flow cytometry, and catalase (CAT) enzyme activity measurement were used to determine genotoxicity, apoptotic effects, and oxidative damage potential, respectively. RESULTS CPBI values and the number of viable cells decreased; the number of late apoptotic and necrotic cells, micronucleus frequency, and comet assay parameters (GDI and DCP) increased; an increase in CAT enzyme levels was observed at 10 and 20 µg/mL concentrations, and CAT enzyme activity was inhibited at 40 µg/mL. [3]
In vivo	METHODS: Sulfoxaflor (GF 2032) (25, 100, and 500 mg/kg, gavage, 4 weeks) was administered to rats and the relative testicular mass, testosterone, FSH, LH, MDA, and GPx levels, sperm motility, sperm morphology, sperm DNA damage, and histopathological changes in the testis, epididymis, and seminal vesicle were examined. RESULTS Sulfoxaflor exposure resulted in an increase in FSH, LH, MDA, and GPx levels in sperm, as well as the percentage of dead and abnormal sperm and DNA damage in rat sperm. [2]
Synonyms	XDE 208, GF 2372, GF 2032

Chemical Properties

Molecular Weight	277.27
Formula	C₁₀H₁₀F₃N₃OS
Cas No.	946578-00-3
Smiles	C(S(=NC#N)(C)=O)(C)C=1C=CC(C(F)(F)F)=NC1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (198.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.21 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6066 mL	18.0330 mL	36.0659 mL	180.3296 mL
5 mM	0.7213 mL	3.6066 mL	7.2132 mL	36.0659 mL
10 mM	0.3607 mL	1.8033 mL	3.6066 mL	18.0330 mL
20 mM	0.1803 mL	0.9016 mL	1.8033 mL	9.0165 mL
50 mM	0.0721 mL	0.3607 mL	0.7213 mL	3.6066 mL
100 mM	0.0361 mL	0.1803 mL	0.3607 mL	1.8033 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc