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Oxotremorine sesquifumarate

Catalog No. T23116   CAS 17360-35-9

Oxotremorine sesquifumarate is a muscarinic agonist.

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Oxotremorine sesquifumarate Chemical Structure
Oxotremorine sesquifumarate, CAS 17360-35-9
Pack Size Availability Price/USD Quantity
5 mg In stock $ 57.00
10 mg In stock $ 93.00
25 mg In stock $ 189.00
50 mg In stock $ 278.00
100 mg In stock $ 418.00
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Purity: 99.94%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Oxotremorine sesquifumarate is a muscarinic agonist.
In vitro Oxotremorine (10.5 micron) produced a paralytic effect on twitch responses of rat diaphragm in vitro to direct and indirect stimulation[1].
In vivo Rats with signs of neuropathy were subjected to SCS applied in awake, freely moving condition. Oxotremorine was administered intrathecally. Tactile, cold and heat sensitivities were assessed by using von Frey filaments, cold spray and focused radiant heat, respectively. Oxotremorine i.t. dose-dependently suppressed the tactile hypersensitivity. SCS markedly increased withdrawal thresholds (WTs), withdrawal latencies and cold scores[2].
Molecular Weight 380.4
Formula C12H18N2O·1·5C4H4O4
CAS No. 17360-35-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: < 28 mg/mL (73.61 mM)

H2O: < 8 mg/mL (21.03 mM)

TargetMolReferences and Literature

1. M Das, D K Ganguly, et al. Enhancement by oxotremorine of acetylcholine release from the rat phrenic nerve. Br J Pharmacol. 1978 Feb;62(2):195-8. 2. Zhiyang Song, et al. Muscarinic receptor activation potentiates the effect of spinal cord stimulation on pain-related behavior in rats with mononeuropathy. Neurosci Lett. 2008 May 2;436(1):7-12.

Related compound libraries

This product is contained In the following compound libraries:
Neurotransmitter Receptor Compound Library Anti-Neurodegenerative Disease Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library Anti-Parkinson's Disease Compound Library Bioactive Compound Library Anti-Alzheimer's Disease Compound Library

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Keywords

Oxotremorine sesquifumarate 17360-35-9 Neuroscience AChR Inhibitor mAChR inhibit tremorogenic neurological Muscarinic acetylcholine receptor inhibitor

 

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