Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Ilaprazole, a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumulates in the acidic environment of the secretory canaliculus of the gastric parietal cell where it is converted to an active sulfenamide form that binds to cysteine sulfhydryl groups on the luminal aspect of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production.
Description | Ilaprazole, a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumulates in the acidic environment of the secretory canaliculus of the gastric parietal cell where it is converted to an active sulfenamide form that binds to cysteine sulfhydryl groups on the luminal aspect of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. |
Synonyms | IY-81149 sodium, 艾普拉唑钠 |
Molecular Weight | 388.42 |
Formula | C19H17N4NaO2S |
CAS No. | 172152-50-0 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 71 mg/mL(182.8 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Ilaprazole sodium 172152-50-0 MAPK信号通路 离子通道 Proton pump TOPK oral Ilaprazole acid ulcers IY 81149 inhibit IY-81149 gastric Inhibitor cancer IY-81149 sodium IY81149 pump Proton Pump inhibitor