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Hydroxychloroquine sulfate

Catalog No. T0951   CAS 747-36-4
Synonyms: Acidum iopanoicum, HCQ sulfate

Hydroxychloroquine sulfate (Acidum iopanoicum) inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa.

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Hydroxychloroquine sulfate Chemical Structure
Hydroxychloroquine sulfate, CAS 747-36-4
Pack Size Availability Price/USD Quantity
50 mg In stock $ 48.00
100 mg In stock $ 74.00
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Purity: 99.87%
Purity: 98.92%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Hydroxychloroquine sulfate (Acidum iopanoicum) inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa.
In vitro Hydroxychloroquine Sulfate is a potent inhibitor of autophagy. It prevents lysosomal acidification, thereby interfering with a key step in the autophagic process.HCQ treatment inhibits RCC (renal cell cancer) cell growth, promotes apoptosis, inhibits mitochondrial oxygen consumption, and increases rates of glycolysis[2].
In vivo The treatment of Hydroxychloroquine Sulfate reduces the infarct size in an in vivo rat model of I/R injury and the cardioprotective effect of Hydroxychloroquine is ERK1/2 dependent[3]. In addition, Hydroxychloroquine Sulfate shows an early vascular protective effect. HCQ seems to prevent the occurrence of endothelial dysfunction(ED) in treated animals[4].
Kinase Assay In vitro kinase assays: with purified proteins, recombinant S6 protein and recombinant active P70S6K are incubated in 1x kinase buffer with various amount of HCQ or RAD001 in the presence (25 μM) or absence of ATP for 30 minutes at 30°C. Total and phosphorylated S6 at ser235/236 and ser240/244 are detected by western analysis using phosphospecific antibodies. Note that recombinant GST-tagged S6 (53 kd) is distinguished from endogenous S6 (32 kd) on the western blot.
Cell Research All cells are cultured in RPMI with 10% FBS, 1% glutamine, and 1% Pen/Strep. cells are seeded on the appropriated plates overnight and treated with HCQ (75 or 100 μM) for 48 hours.(Only for Reference)
Synonyms Acidum iopanoicum, HCQ sulfate
Molecular Weight 433.95
Formula C18H26ClN3O·H2SO4
CAS No. 747-36-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Insoluble

H2O: 10 mM

TargetMolReferences and Literature

1. Ramser B, et al.J Invest Dermatol, 2009,129(10):2419-26. 2. Lee HO, et al. PLoS One. 2015, 10(7): e20131464. 3. Bourke L, et al. PLoS One. 2015, 10(12):e0143771. 4. Marta Mosca, et al. 2013 ACR/ARHP Annual Meeting. 5. Lamphier M, et al. Mol Pharmacol. 2014, 85(3):429-440. 6. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6. 7. Xia Z, Zhang X, Liu P, et al. GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner[J]. Cell Death & Disease. 2021, 12(1): 1-11.

TargetMolCitations

1. Xia Z, Zhang X, Liu P, et al. GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner. Cell Death & Disease. 2021, 12(1): 1-11.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Parasitic Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library HIF-1 Signaling Pathway Compound Library Bioactive Compounds Library Max Anti-Lung Cancer Compound Library Orally Active Compound Library Anti-Viral Compound Library Anti-Diabetic Compound Library

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Keywords

Hydroxychloroquine sulfate 747-36-4 Autophagy DNA Damage/DNA Repair Immunology/Inflammation Microbiology/Virology DNA SARS-CoV TLR Parasite Acidum iopanoicum HCQ Inhibitor Toll-like Receptor (TLR) SARS coronavirus Hydroxychloroquine inhibit Hydroxychloroquine Sulfate HCQ sulfate HCQ Sulfate inhibitor

 

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