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Enalapril

Catalog No. T1605 CAS 75847-73-3

Synonyms: MK-421

Enalapril is a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.

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Enalapril, CAS 75847-73-3

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500 mg	In stock	$ 308.00

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Purity: 99.47%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Enalapril is a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.

Kinase Assay

PDGF receptor kinase activity: PDGF receptor is immunoprecipitated from BALB/c 3T3 cell extracts with rabbit antiserum to the murine PDGF receptor for 2 hours on ice. Protein A-Sepharose beads are used to collect the antigen-antibody complexes. The immunoprecipitates are washed twice with TNET (50 mM Tris, pH 7.5, 140 mM NaCl, 5 mM EDTA, 1% Triton X-100), once with TNE (50 mM Tris, pH 7.5, 140 mM EDTA), and once with kinase buffer (20 mM Tris, pH 7.5,10 mM MgCl2). After stimulation with PDGF (50 ng/mL) for 10 minutes at 4 °C, different concentrations of drug are added to the reaction mixture. PDGF receptor kinase activity is determined by incubation with 10 μCi [7-33P]-ATP and l μM ATP for 10 minutes at 4 °C. Immune complexes are separated by SDS-PAGE on 7.5% gels.

Synonyms	MK-421
Molecular Weight	376.45
Formula	C20H28N2O5
CAS No.	75847-73-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Soluble

References and Literature

1. Andujar-Sanchez M, et al. FEBS Lett. 2007 Jul 24;581(18):3449-54.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Approved Drug Library Anti-Hypertension Compound Library Bioactive Compound Library FDA-Approved Drug Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Delapril hydrochloride Araloside A Pivalopril Angiotensin II 5-valine TFA Ceronapril Pomisartan 2HCl Zofenopril calcium Aliskiren D6 hemifumarate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Enalapril 75847-73-3 Endocrinology/Hormones Immunology/Inflammation MRP RAAS ACE inhibitor MK-421 Antihypertensives Inhibitor inhibit MK421 MK 421 Angiotensin-converting Enzyme (ACE) inhibitor

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